Accumulation of SNAP25 in mouse gustatory and somatosensory cortices in response to food and chemical stimulation
Accumulation of SNAP25 in mouse gustatory and somatosensory cortices in response to food and chemical stimulation
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SNAP25 在小鼠味觉和体感皮层中积累以响应食物和化学刺激
DOI：
10.1016/j.neuroscience.2012.05.045
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发表时间：
2012
期刊：
影响因子：
3.3
通讯作者：
et. al.
中科院分区：
文献类型：
--
作者：
Kawakami;S.;et. al.
食物摄入刺激，包括味觉、体感和触觉刺激，由口腔内的感受器接收，然后这些信息被转移到大脑皮层。断奶期间近期摄入食物的信号可以影响突触传递，导致大脑皮层的生化变化，从而改变味觉和体感神经系统的可塑性。在本研究中，我们研究了断奶期间小鼠味觉和体感觉皮层中分子标记的表达模式。突触体相关蛋白25 （SNAP25）是可溶性n -乙基马来酰亚胺敏感因子附着蛋白受体（SNARE）复合物的一个组成部分，与出生后第2周相比，在出生后第3周，突触体相关蛋白25 （SNAP25）在岛皮层和体感觉皮层的表达增加。此外，在断奶阶段，饲喂固体食物的断奶小鼠大脑皮层中的SNAP25蛋白积累，而仅饲喂母乳的小鼠则没有。断奶期糖精或辣椒素的化学刺激也分别增加了脑岛区或体感觉皮质区SNAP25的免疫反应性。这些结果表明，断奶期间口腔内近期摄入的化学信号增加了味觉和体感皮层中SNAP25的积累，并促进了味觉和体感神经系统发育过程中的神经可塑性。
Food intake stimuli, including taste, somatosensory, and tactile stimuli, are received by receptors in the oral cavity, and this information is then transferred to the cerebral cortex. Signals from recently ingested food during the weaning period can affect synaptic transmission, resulting in biochemical changes in the cerebral cortex that modify gustatory and somatosensory nervous system plasticity. In this study, we investigated the expression patterns of molecular markers in mouse gustatory and somatosensory cortices during the weaning period. The expression of synaptosomal-associated protein 25 (SNAP25), a component of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, was increased in the insular and somatosensory cortices at postnatal week 3 compared to postnatal week 2. Additionally, SNAP25 protein in the cerebral cortex accumulated in weaning mice fed solid food but not in mice fed only mother’s milk at the weaning stage. Chemical stimulation by saccharin or capsaicin at the weaning stage also increased SNAP25 immunoreactivity in the insular or somatosensory cortical area, respectively. These results suggest that recently ingested chemical signals in the oral cavity during weaning increase the accumulation of SNAP25 in the gustatory and somatosensory cortices and promote neural plasticity during the development of the gustatory and somatosensory nervous systems.
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影响因子：
2.9
作者：
R. Norgren;G. Wolf
通讯作者：
G. Wolf
大鼠颗粒状和颗粒异常岛叶皮质味觉神经元感受野特征的差异
影响因子：
2
作者：
H. Ogawa;N. Murayama;K. Hasegawa
通讯作者：
K. Hasegawa
不同年龄大鼠皮质两个味觉区神经元反应特性的变化
DOI：
--
发表时间：
1994
期刊：
Neurosciences research
影响因子：
--
作者：
H. Ogawa;K. Hasegawa;M. Ohgushi;N. Murayama
通讯作者：
N. Murayama
通过刺激整个口腔来识别大鼠颗粒状和颗粒状异常岛皮质的味觉区
DOI：
--
发表时间：
1990
期刊：
Neurosciences research
影响因子：
--
作者：
H. Ogawa;S. Ito;N. Murayama;K. Hasegawa
通讯作者：
K. Hasegawa
影响因子：
16.2
作者：
Selak, Sanja;Paternain, Ana V.;Lerma, Juan
通讯作者：
Lerma, Juan