Directional dependent variation in mechanical properties of planar anisotropic porcine skin tissue
Directional dependent variation in mechanical properties of planar anisotropic porcine skin tissue
复制标题
DOI：
10.1016/j.jmbbm.2020.103693
复制
发表时间：
2020-04-01
影响因子：
3.9
通讯作者：
Kumar, Navin
中科院分区：
文献类型：
--
作者：
Lakhani, Piyush;Dwivedi, Krashn K.;Kumar, Navin
皮肤的非线性和各向异性力学行为在各种应用中是必不可少的，例如皮肤病学、化妆品、法医学和计算研究。本研究采用膨胀法和全视野成像技术对皮肤的力学各向异性进行量化。在膨胀中，37 ℃的盐水溶液模拟体内体温和流体条件，并且所有实验都在对照环境中进行。应用薄球壳薄膜理论的假设和成像技术，得到了各向异性应力应变关系。此外，计算10度间隔处的应力应变关系以获得模量随方向的变化。进行组织学检查以表明胶原纤维取向对机械性能的作用。最大和最小线性模量和胶原纤维取向强度被发现有很好的一致性。最大和最小线性模量和取向强度之间的角度差分别为71度+/-7度和76度+/-5度，百分比差分别为43.4 +/-8.2和52.5 +/-6.4。此外，未测试和测试样本之间的最大和最小胶原蛋白取向强度的显著差异表明纤维的重新排列。此外，建立了一个三次多项式的经验关系，以计算的定量变化的表观模量与方向，这服务于各向异性建模的皮肤。在这项研究中使用的实验技术可以应用于平面软组织的各向异性量化，以及可以用来模仿重建手术中使用的组织扩张程序。
Nonlinear and anisotropic mechanical behavior of skin is essential in various applications such as dermatology, cosmetic products, forensic science, and computational studies. The present study quantifies the mechanical anisotropy of skin using the bulge method and full-field imaging technique. In bulging, the saline solution at 37 degrees C mimics the in vivo body temperature and fluid conditions, and all experiments were performed in the control environment. Assumption of thin spherical shell membrane theory and imaging techniques were implemented to obtain the anisotropic stress strain relations. Further, stress strain relations at an interval of 10 degrees were calculated to obtain the variation in modulus with direction. Histological examinations were performed to signify the role of the collagen fibers orientation on the mechanical properties. The maximum and minimum linear modulus and collagen fiber orientation intensity were found in good agreement. The angular difference between maximum and minimum linear modulus and orientation intensity was found 71 degrees +/- 7 degrees and 76 degrees +/- 5 degrees respectively, and the percentage difference was 43.4 +/- 8.2 and 52.5 +/- 6.4 respectively. Further, a significant difference in the maximum and minimum collagen orientation intensity between the untested and tested specimens indicates the realignment of the fibers. Additionally, a cubic polynomial empirical relation was established to calculate the quantitative variation in the apparent modulus with the directions, which serves for the anisotropic modeling of the skin. The experimental technique used in this study can be applied for anisotropic quantification of planar soft tissues as well as can be utilized to imitate the tissue expansion procedure used in reconstructive surgery.