New drugs for neglected infectious diseases: Chagas' disease.
New drugs for neglected infectious diseases: Chagas' disease.
复制标题
治疗被忽视的传染病的新药：恰加斯病。
DOI：
10.1111/j.1476-5381.2010.00662.x
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发表时间：
2010
影响因子：
7.3
通讯作者：
Teixeira,MauroM
中科院分区：
文献类型：
--
作者：
Machado,FabianaS;Tanowitz,HerbertB;Teixeira,MauroM
恰加斯病（CD）是由克氏锥虫（Tc）引起的，是导致发病率和死亡率的重要原因。该领域的大多数研究人员现在都认为，慢性低级别寄生虫在组织中的持久性驱动组织损伤和CD的自身免疫成分。目前的治疗依赖于两种化合物：苯并硝唑和硝呋替莫。尽管这两种化合物在治疗乳糜泻方面有着悠久的历史，但它们都会引起显著的副作用。在本期的《印度人民党》杂志上，两篇文章表明，NO -供体在体外和体内实验模型中对Tcin有活性，尤其是与苯并硝唑联合使用时。作者开发新型抗Tc化合物的基本概念依赖于一氧化氮杀死寄生虫的能力。有几个问题仍有待解决，但报告的研究是该领域的一个明显进步，应该考虑进一步的临床前开发。这篇文章是对西尔瓦埃尔的评论。，第260-269页和Guedeset等。，第270-282页。浏览这些论文请访问http://dx.doi.org/10.1111/j.1476‐5381.2010.00524.x和http://dx.doi.org/10.1111/j.1476‐5381.2010.00576.x
Chagas' disease (CD) is caused by the protozoanTrypanosoma cruzi(Tc) and remains an important cause of morbidity and mortality. Most researchers in the field now agree that chronic low grade parasite persistence in tissue drives tissue damage and the autoimmune component of CD. Current therapy relies on two compounds: benznidazole and nifurtimox. Despite their long history in the treatment of CD, both compounds induce significant side‐effects. In the current issue of theBJP, two contributions demonstrate that NO‐donors are active, especially in combination with benznidazole, against Tcin vitroand in experimental modelsin vivo. The basic concept used by the authors to develop novel anti‐Tc compounds relied on the demonstrated ability of nitric oxide to kill the parasite. There are several issues still to be resolved but the reported studies are a clear advance to the field and should be considered for further pre‐clinical development.This article is a commentary on Silvaet al., pp. 260–269 and Guedeset al., pp. 270–282 of this issue. To view these papers visit http://dx.doi.org/10.1111/j.1476‐5381.2010.00524.x and http://dx.doi.org/10.1111/j.1476‐5381.2010.00576.x