Impaired declarative memory consolidation during sleep in patients with primary insomnia: Influence of sleep architecture and nocturnal cortisol release
Impaired declarative memory consolidation during sleep in patients with primary insomnia: Influence of sleep architecture and nocturnal cortisol release
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DOI：
10.1016/j.biopsych.2006.03.051
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发表时间：
2006-12-15
影响因子：
10.6
通讯作者：
Hohagen, Fritz
中科院分区：
文献类型：
--
作者：
Backhaus, Jutta;Junghanns, Klaus;Hohagen, Fritz
背景：睡眠的核心认知功能是巩固新获得的记忆以进行长期存储。在这里，我们调查了声明性记忆住院患者与慢性睡眠障碍的隔夜巩固是否受损，这是由于慢速睡眠（SWS）和皮质醇释放量增加而受损。方法：Polysomnograpbic记录，血清皮质醇浓度，以及16例患者的过夜记忆巩固将主要失眠与13个健康对照主题的失眠症进行了比较。分子：一夜之间显示出明显较少的患者声明性记忆的合并（p <.05），与对照组中的SWS显着相关（r = .69），但患者的眼睛运动快速运动（r = .56），他们不好SWS的数量（p <.05）。半夜的皮质醇水平升高与对照组受试者（r = -.52）和患者（r = -.46）的睡眠后陈述记忆的检索受损有关。与声明性记忆相关的合并。在夜间的早期，声明性记忆的有效隔夜巩固与大量的SWS和低血清皮质醇水平有关。如果SWS减少，REM睡眠可能在声明性记忆的巩固中起部分补偿性作用。
Background: A central cognitive,function of sleep is to consolidate newly acquired memories for long-term storage. Here, we investigated whether the overnight consolidation of declarative memory inpatients with chronic sleep disturbances is impaired, owing to less slow wave sleep (SWS) and an increased cortisol release.Methods: Polysomnograpbic recordings, serum cortisol concentrations, and overnight memory consolidation in 16 patients with primary insomnia were compared with those of 13 healthy control subjects.Results: Patients displayed distinctly less overnight consolidation of declarative memory (p < .05), which was significantly correlated with SWS in the control subjects (r = .69) but with rapid eye movement (REM) sleep in the patients (r = .56), who bad a diminished amount of SWS (p < .05). Increased cortisol levels in the middle of the night were associated with impaired retrieval of declarative memory after sleep for both control subjects (r = -.52) and patients (r = -.46).Conclusions: Primary insomnia is associated with a diminished sleep-related consolidation of declarative memory. Efficient overnight consolidation of declarative memory is associated with high amounts of SWS and low serum cortisol levels during the early part of the night. Where SWS is decreased, REM sleep might play a partly compensatory role in the consolidation of declarative memory.