FIBROBLAST GROWTH FACTOR-23 AND HYPOPHOSPHATEMIA IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS
FIBROBLAST GROWTH FACTOR-23 AND HYPOPHOSPHATEMIA IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS
复制标题
DOI：
10.2478/v10011-011-0031-5
复制
发表时间：
2012-01-01
影响因子：
2.5
通讯作者：
Suleman, Moosa
中科院分区：
文献类型：
--
作者：
Elsammak, Mohamed Y.;Attia, Adel;Suleman, Moosa
受损的血清磷酸盐水平可能导致呼吸肌无力，进一步对慢性阻塞性肺疾病（COPD）患者产生负面影响。最近，成纤维细胞生长因子23（FGF-23）已被证明在体内磷酸盐的调节中发挥重要作用。本研究包括2组：70名COPD患者和34名对照受试者。采集血样进行一系列常规实验室检查。使用市售ELISA试剂盒测量FGF-23。患者组血浆FGF-23水平显著高于对照组（P= 0.000）。与对照组相比，COPD患者肾小管对磷酸盐的最大吸收显著降低（P=0.04）。血浆FGF-23与FEV 1和血清白蛋白呈负相关。在COPD患者中发现的血浆FGF-23水平升高与疾病严重程度相关，可能是导致低血清磷的另一个因素。
Impaired serum phosphate levels may contribute to respiratory muscle weakness that further negatively impacts Chronic Obstructive Pulmonary Disease (COPD) patients. Recently, Fibroblast Growth Factor 23 (FGF-23) has been shown to play an important role in the regulation of body phosphate. The current study includes 2 groups: 70 COPD patients and 34 control subjects. Blood samples were taken for a panel of routine lab tests. FGF-23 was measured using a commercially available ELISA kit. Plasma FGF-23 levels were significantly higher in the patient group compared to the control group (P= 0.000). Tubular maximum absorption of phosphate was significantly reduced in COPD patients compared to the control group (P=0.04). Plasma FGF-23 negatively correlated with FEV1 and serum albumin. Elevated plasma FGF-23 levels found in COPD patients correlated with disease severity and may represent an additional factor causing low serum phosphate.