The Epilepsy Surgery Grading Scale: Validation in an independent population with drug-resistant focal epilepsy
The Epilepsy Surgery Grading Scale: Validation in an independent population with drug-resistant focal epilepsy
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DOI：
10.1111/epi.16096
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发表时间：
2019-08-01
期刊：
影响因子：
5.6
通讯作者：
Depondt, Chantal
中科院分区：
文献类型：
--
作者：
Conte, Francesca;Van Paesschen, Wim;Depondt, Chantal
癫痫手术分级量表（ESGS）是一个简单的工具，可预测患者进展到切除手术并成为无癫痫的可能性。我们研究的目的是在一个独立的患者队列中验证ESGS。我们回顾性计算了在比利时两个耐药癫痫参考中心接受术前评估的耐药局灶性癫痫成人患者的ESGS评分。我们将患者分为ESGS 1级（最有利）、2级（中等）和3级（最不利）。我们评估了手术进展和术后癫痫发作自由度。共有238例患者接受了术前评价（术前队列），其中140例进展为手术（手术队列）。在术前队列中，我们观察到1级、2级和3级患者的手术率和无癫痫发作率存在显著差异。在手术队列中，我们观察到1级和2级之间以及1级和3级之间的癫痫发作自由率存在显著差异。我们证实了ESGS对接受术前评估的耐药局灶性癫痫患者的预后分层的有用性。我们的研究结果支持使用的ESGS在临床实践中的术前评估的决策过程。
The Epilepsy Surgery Grading Scale (ESGS) is a simple tool that predicts a patient's likelihood of progressing to resective surgery and becoming seizure-free. The aim of our study was to validate the ESGS in an independent patient cohort. We retrospectively calculated the ESGS score for adult patients with drug-resistant focal epilepsy undergoing presurgical evaluation at two reference centers for drug-resistant epilepsy in Belgium. We classified patients into ESGS grade 1 (most favorable), grade 2 (intermediate), and grade 3 (least favorable). We assessed progression to surgery and postsurgical seizure freedom. A total of 238 patients underwent presurgical evaluation (presurgical cohort), of whom 140 progressed to surgery (surgical cohort). In the presurgical cohort, we observed significant differences in rates of surgery and in rates of seizure freedom between grades 1, 2, and 3. In the surgical cohort, we observed significant differences in rates of seizure freedom between grades 1 and 2 and between grades 1 and 3. We confirm the usefulness of the ESGS for the prognostic stratification of patients with drug-resistant focal epilepsy undergoing presurgical evaluation. Our results support the use of the ESGS in the decision process of presurgical evaluation in clinical practice.