The Effects of Dehydration Temperature and Monomer Chirality on Primitive Polyester Synthesis and Microdroplet Assembly
The Effects of Dehydration Temperature and Monomer Chirality on Primitive Polyester Synthesis and Microdroplet Assembly
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DOI：
10.1002/macp.202200235
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发表时间：
2022-09-04
影响因子：
2.5
通讯作者：
Jia, Tony Z.
中科院分区：
文献类型：
--
作者：
Afrin, Rehana;Chen, Chen;Jia, Tony Z.
通过α-羟基酸（α HAs）脱水合成聚酯凝胶是形成原始功能聚合物的合理途径。α HA聚酯凝胶在水介质中再水化后组装成无膜液滴，其可以分离和区室化早期生物分子。然而，聚酯合成和微滴组装的条件还有待广泛探索。因此，热和单体手性的脱水合成和组装的均聚酯微滴的影响进行了研究，使用显微镜和质谱。更低的脱水温度（
Synthesis of polyester gels via dehydration of alpha-hydroxy acids (alpha HAs) is a plausible route to form primitive functional polymers. alpha HApolyester gels assemble into membraneless droplets upon rehydration in aqueous media that can segregate and compartmentalize early biomolecules. However, conditions for polyester synthesis and microdroplet assembly have yet to be broadly explored. Thus, the effects of heat and monomer chirality on dehydration synthesis and assembly of homopolyester microdroplets are investigated using microscopy and mass spectrometry. Lower dehydration temperatures (