Vav proteins, adaptors and cell signaling
Vav proteins, adaptors and cell signaling
复制标题
DOI：
10.1038/sj.onc.1204780
复制
发表时间：
2001-10-01
期刊：
影响因子：
8
通讯作者：
Bustelo, XR
中科院分区：
文献类型：
--
作者：
Bustelo, XR
Vav家族是一组具有致癌潜能的信号转导分子，在发育和细胞信号传导中发挥重要作用。该家族成员分布于所有多细胞动物中，但不存在于单细胞生物中。近期的基因组研究表明，Vav蛋白的功能与酪氨酸激酶途径共同进化，可能是为了确保细胞外信号最佳地转化为与细胞骨架和基因转录相关的生物学反应。到目前为止，Vav蛋白最为人熟知的功能是作为Rho/Rac分子的GDP/GTP交换因子，这一功能受到酪氨酸磷酸化的严格调控。近期的文献表明，该功能高度依赖于衔接蛋白的相互作用，这些衔接蛋白有助于Vav蛋白的适当磷酸化、它们与其他信号分子的相互作用以及调节其信号输出的强度。除了作为交换因子的功能外，越来越多的证据表明，Vav蛋白可以独立于其交换活性介导其他细胞功能，可能是通过自身作为衔接分子发挥作用。在这篇综述中，我们将总结该领域的最新进展，特别强调Vav的非催化作用及其与其他衔接分子的相互作用。
The Vav family is a group of signal transduction molecules with oncogenic potential that play important roles in development and cell signaling. Members of this family are distributed in all animal metazoans but not in unicellular organisms. Recent genomic studies suggest that the function of Vav proteins co-evolved with tyrosine kinase pathways, probably to assure the optimal conversion of extracellular signals into biological responses coupled to the cytoskeleton and gene transcription. To date, the best-known function of Vav proteins is their role as GDP/GTP exchange factors for Rho/Rac molecules, a function strictly controlled by tyrosine phosphorylation. Recent publications indicate that this function is highly dependent on the interaction of adaptor proteins that aid in the proper phosphorylation of Vav proteins, their interaction with other signaling molecules, and in modulating the strength of their signal outputs. In addition to the function of Vav proteins as exchange factors, there is increasing evidence suggesting that Vav proteins can mediate other cellular functions independently of their exchange activities, probably by working themselves as adaptor molecules. In this review, we will give a summary of the recent advances in this field, placing special emphasis on the non-catalytic roles of Vav and its interaction with other adaptor molecules.