Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice
Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice
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DOI：
10.1016/j.bbrc.2010.06.029
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发表时间：
2010-07-09
影响因子：
3.1
通讯作者：
Kaisho, Tsuneyasu
中科院分区：
文献类型：
--
作者：
Yamazaki, Chihiro;Miyamoto, Rie;Kaisho, Tsuneyasu
了解树突状细胞 (DC) 子集的功能应该有助于新型疫苗的开发。在这里，我们表征了 XC 趋化因子受体 1 (XCR1) 及其配体 XCL1 的表达。鼠XCR1是CD8α(+)常规DC中唯一选择性表达的趋化因子受体。 XCL1 在 NK 细胞中组成型表达，这有助于血清 XCL1 水平。 NK 和 CD8(+) T 细胞在激活后增加了 XCL1 的产生。这些表达模式在人类血细胞中是保守的，包括 BDCA3(+) DC 亚群。因此，在人和小鼠中，某些 DC 亚群应该通过 XCR1 对 NK 或激活的 CD8(+) T 细胞趋化。 (C) 2010 Elsevier Inc. 保留所有权利。
Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8 alpha(+) conventional DCs. XCL1 was constitutively expressed in NK cells, which contribute to serum XCL1 levels. NK and CD8(+) T cells increased XCL1 production upon activation. These expression patterns were conserved in human blood cells, including the BDCA3(+) DC subset. Thus, in human and mice, certain DC subsets should be chemotactic towards NK or activated CD8(+) T cells through XCR1. (C) 2010 Elsevier Inc. All rights reserved.