Periodic migration in a physical model of cells on micropatterns.
Periodic migration in a physical model of cells on micropatterns.
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DOI：
10.1103/physrevlett.111.158102
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发表时间：
2013-10-11
影响因子：
8.6
通讯作者：
Rappel WJ
中科院分区：
文献类型：
--
作者：
Camley BA;Zhao Y;Li B;Levine H;Rappel WJ
我们扩展了爬行真核细胞的形态和动力学模型来描述微图案化基底上的细胞。该模型将细胞形态、粘附和细胞骨架流动耦合起来，以响应肌动蛋白和肌球蛋白诱导的主动应力。我们建议，膨胀应力只产生在细胞粘附，导致细胞的有效限制的模式。与实验结果一致，模拟细胞表现出广泛的行为，包括稳定运动，转向，双足运动和周期性迁移，其中细胞在周期性逆转之前持续地在一个方向上爬行。我们表明，周期性运动自然出现的细胞极化细胞形状的耦合，通过减少模型简化的一维形式，可以理解的分析。
We extend a model for the morphology and dynamics of a crawling eukaryotic cell to describe cells on micropatterned substrates. This model couples cell morphology, adhesion, and cytoskeletal flow in response to active stresses induced by actin and myosin. We propose that protrusive stresses are only generated where the cell adheres, leading to the cell's effective confinement to the pattern. Consistent with experimental results, simulated cells exhibit a broad range of behaviors, including steady motion, turning, bipedal motion, and periodic migration, in which the cell crawls persistently in one direction before reversing periodically. We show that periodic motion emerges naturally from the coupling of cell polarization to cell shape by reducing the model to a simplified one-dimensional form that can be understood analytically.