ANTIMYCIN-INSENSITIVE OXIDATION OF SUCCINATE AND REDUCED NICOTINAMIDE-ADENINE DINUCLEOTIDE IN ELECTRON-TRANSPORT PARTICLES .2. STEROID EFFECTS
ANTIMYCIN-INSENSITIVE OXIDATION OF SUCCINATE AND REDUCED NICOTINAMIDE-ADENINE DINUCLEOTIDE IN ELECTRON-TRANSPORT PARTICLES .2. STEROID EFFECTS
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DOI：
10.1016/0926-6593(66)90058-0
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发表时间：
1966-01-01
期刊：
影响因子：
--
通讯作者：
JENSEN, PK
中科院分区：
文献类型：
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作者：
JENSEN, PK
以琥珀酸为底物的脱氧皮质酮可抑制生理 pH 下电子传输颗粒中的抗霉素不敏感氧化。当底物是还原型烟酰胺腺嘌呤二核苷酸并且类固醇浓度低时，会刺激氧化，但高类固醇浓度会抑制氧化。 Amytal 也有类似的作用。类固醇对还原型烟酰胺腺嘌呤二核苷酸氧化的影响的差异是类固醇诱导的抗霉素不敏感氧化的pH曲线向酸方向移动的结果，其中移动的幅度取决于类固醇浓度。类固醇的作用似乎与抗霉素不敏感氧化过程中 H2O2 的形成有关。
Antimycin-insensitive oxidation in electron-transport particles at physiological pH is inhibited by deoxycortlcoster-one with succinate as substrate. When the substrate is reduced nicotinamide-adenine dinucleotide and the steroid concentration is low, oxidation is stimulated, but high steroid concentrations are inhibitory. Amytal has similar effects. The divergence of the effect of steroid on the oxidation of reduced nicotinamide-adenine dinucleotide is a consequence of a steroid-induced shift in acid direction of the pH curve for antimycin-insensitive oxidation, where the magnitude of the shift depends on steroid concentration. The effect of steroid appears to be associated with the formation of H2O2 during antimycin-insensitive oxidation.