Superoxide flashes, reactive oxygen species, and the mitochondrial permeability transition pore: potential implications for hematopoietic stem cell function
Superoxide flashes, reactive oxygen species, and the mitochondrial permeability transition pore: potential implications for hematopoietic stem cell function
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DOI：
10.1097/moh.0b013e3283475ffe
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发表时间：
2011-07-01
影响因子：
3.2
通讯作者：
Broxmeyer, Hal E.
中科院分区：
文献类型：
--
作者：
Mantel, Charlie;Messina-Graham, Steven V.;Broxmeyer, Hal E.
综述目的活性氧（ROS）在血细胞稳态和造血疾病中具有重要作用。最近的发现，关于如何ROS的产生和调节线粒体通过线粒体通透性转换孔（mPTP）和新的现象，超氧化物闪光，ROS诱导的ROS释放，尚未在造血干细胞和祖细胞中进行研究，但可能有重要的影响，他们的调节和生存。在这里，我们涉及我们的意见，这些潜在的implications.Recent findingsThe mPTP最近已牵连ROS生成通过绑定Stat3转录因子的一个中央组成部分的pore.SummaryThe的影响，这一新的信息造血调节和移植方法可能被证明是重要的，特别是因为它们涉及到髓系肿瘤肿瘤的发生和潜在的新的治疗靶点。关于ROS产生的新细节表明，骨髓和脐带血收获技术可能受益于下调ROS的方法。
Purpose of reviewReactive oxygen species (ROS) have an important function in blood cell homeostasis and hematopoietic diseases. Recent discoveries concerning how ROS are generated and regulated in mitochondria via the mitochondrial permeability transition pore (mPTP) and the new phenomenon, superoxide flashes, and ROS-induced ROS release, have not been investigated in hematopoietic stem and progenitor cells, but likely have important implications for their regulation and survival. Here we relate our opinions about these potential implications.Recent findingsThe mPTP has been recently implicated in ROS generation via binding of Stat3 transcription factor to a central component of the pore.SummaryThe implications of this new information for hematopoiesis regulation and transplantation methodologies could prove to be important, especially as they relate to myeloid neoplasm oncogenesis and potentially new therapeutic targets. New details about ROS production suggest that techniques for bone marrow and umbilical cord blood harvest may benefit from means to downmodulate ROS.