Polymers with amino acids in their side chain : conformation of polymers derived from glycylglycine and phenylalanine
Polymers with amino acids in their side chain : conformation of polymers derived from glycylglycine and phenylalanine
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侧链带有氨基酸的聚合物：甘氨酰甘氨酸和苯丙氨酸衍生的聚合物的构象
DOI：
10.1021/ma00084a027
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发表时间：
1994
期刊：
影响因子：
5.5
通讯作者：
M. Morcellet
中科院分区：
文献类型：
--
作者：
Costas Methenitis;J. Morcellet;G. Pneumatikakis;M. Morcellet
通过自由基聚合反应合成了侧链分别含有甘氨酰甘氨酸（PGlyGly）和苯丙氨酸（PPhe）的聚甲基丙烯酰胺[CH2 C（CH3）CONHCH（COOH）] n和[CH2 C（CH3）CONHCH（COOH）CH2 C6 H5] n。PGlyGly表现为与其亲水性质相关的正常构象。相反，PPhe在水中采取紧凑的构象。这种构象的稳定自由焓是高的电位滴定所揭示的。考察了添加剂（金属离子、尿素、有机溶剂）对聚合物的紧密构象和pH诱导的构象转变的影响
Polymethacrylamides [CH 2 C(CH 3 )CONH(CH 2 CONHCH 2 COOH)] n and [CH 2 C(CH 3 )CONHCH(COOH)CH 2 C 6 H 5 ] n bearing glycylglycine (PGlyGly) and phenylalanine (PPhe) in the side chain were synthesized by free radical polymerization of the corresponding monomers. PGlyGly behaves as a normal polyelectrolyte in relation with its hydrophilic nature. On the contrary PPhe takes a compact conformation in water. The free enthalpy of stabilization of this conformation is high as revealed by potentiometric titrations. The influence of some additives (metal ion, urea, organic solvent) on the compact conformation and the pH-induced conformational transition was investigated