THEORY OF EPIGENESIS OF NEURONAL NETWORKS BY SELECTIVE STABILIZATION OF SYNAPSES
THEORY OF EPIGENESIS OF NEURONAL NETWORKS BY SELECTIVE STABILIZATION OF SYNAPSES
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DOI：
10.1073/pnas.70.10.2974
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发表时间：
1973-01-01
影响因子：
11.1
通讯作者：
DANCHIN, A
中科院分区：
文献类型：
--
作者：
CHANGEUX, JP;COURREGE, P;DANCHIN, A
介绍了一种形式主义来表示一个不断发展的神经元网络的连接组织和环境对这个组织的影响与功能相关的不稳定突触的稳定或退化。学习，或者说一种联想性质的获得，与联结组织的一种特征性变异有关：环境与遗传程序的相互作用通过神经元的功能被印成这种组织的一种特定模式。应用该理论的神经肌肉接头的发展提出和学习的基本选择方面强调。
A formalism is introduced to represent the connective organization of an evolving neuronal network and the effects of environment on this organization by stabilization or degeneration of labile synapses associated with functioning. Learning, or the acquisition of an associative property, is related to a characteristic variability of the connective organization: the interaction of the environment with the genetic program is printed as a particular pattern of such organization through neuronal functioning. An application of the theory to the development of the neuromuscular junction is proposed and the basic selective aspect of learning emphasized.