LOCALIZATION OF METABOLITES IN ANIMALS USING P-31 TOPICAL MAGNETIC-RESONANCE
LOCALIZATION OF METABOLITES IN ANIMALS USING P-31 TOPICAL MAGNETIC-RESONANCE
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DOI：
10.1038/287736a0
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发表时间：
1980-01-01
期刊：
影响因子：
64.8
通讯作者：
CHAN, L
中科院分区：
文献类型：
--
作者：
GORDON, RE;HANLEY, PE;CHAN, L
生物分子的高分辨率31 P-NMR光谱提供了有关生命系统代谢的详细信息。虽然核磁共振方法是非破坏性的，但迄今为止的所有研究，除了2个例外，都是在切除的灌注器官和组织上进行的，或者需要某种形式的手术进行原位测量。表面射频线圈的使用不需要手术，但最适合接近动物表面的组织。这里描述的是一种局部磁共振，一种新的，非手术的方法，用于获取31 P-NMR光谱从选定的，局部的地方深入动物通过修改主磁场，Bo，只使用静态场梯度。该方法在概念上类似于1自旋成像方法，但主要提供生化信息而不是空间信息。这一新技术可用于生命系统的基础研究、临床诊断和药物疗效的评估。
High-resolution 31P-NMR spectra of biological molecules provide detailed information about the metabolism of living systems. Although the NMR method is non-destructive, all studies so far, with 2 exceptions, have been carried out on excised, perfused organs and tissues or have required some form of surgery for in situ measurements. The use of surface radiofrequency coils does not require surgery but is best suited for tissues close to the surface of the animals. Described here is a topical magnetic resonance, a new, non-surgical method for acquiring 31P-NMR spectra from a selected, localized place deep within an animal by modifying the main magnetic field, Bo, using only static-field gradients. The method is conceptually similar to 1 spin-imaging method but primarily provides biochemical rather than spatial information. This new technique can be used in fundamental investigations into living systems, clinical diagnosis and the estimation of the efficacy of drug therapy.