Palladium(0)-Catalyzed Intermolecular Carbocyclization of (1,n)-Diynes and Bromophenols: An Efficient Route to Tricyclic Scaffolds
Palladium(0)-Catalyzed Intermolecular Carbocyclization of (1,n)-Diynes and Bromophenols: An Efficient Route to Tricyclic Scaffolds
复制标题
钯 (0) 催化 (1,n)-二炔和溴酚的分子间碳环化：制备三环支架的有效途径
DOI：
10.1002/anie.201601570
复制
发表时间：
2016-06-06
影响因子：
16.6
通讯作者：
Luan, Xinjun
中科院分区：
文献类型：
--
作者：
Bai, Lu;Yuan, Yini;Luan, Xinjun
在钯（0）催化下，溴代苯酚与（1，n）-二炔的脱芳环化反应得到了两种新型的含季碳中心的三环结构。该方法使用廉价的溴苯酚和容易获得的栓系二炔。它表现出广泛的底物范围，并容忍各种官能团。与市售的手性配体的初步结果表明，对映选择性的变体是可行的两个环化过程。
A novel palladium(0)-catalyzed dearomative cyclization reaction of bromophenols with (1,n)-diynes has been developed for building two new types of tricyclic architectures containing a quaternary carbon center. This method employs inexpensive bromophenols, and easily accessible tethered diynes. It exhibits a broad substrate scope and tolerates various functional groups. Preliminary results with commercially available chiral ligands indicate that enantioselective variants are feasible for both cyclization processes.