Nucleocytoplasmic relations in a mutator-suppressor system of Drosophila ananassae.
Nucleocytoplasmic relations in a mutator-suppressor system of Drosophila ananassae.
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果蝇突变抑制系统中的核细胞质关系。
DOI：
10.1093/genetics/98.1.77
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发表时间：
1981
期刊：
影响因子：
3.3
通讯作者：
Hinton,CW
中科院分区：
文献类型：
--
作者：
Hinton,CW
一个部分特征的突变子-抑制系统，以前在果蝇的囊膜中被发现，被证明存在于果蝇的祖先种群中；它包括一个精子染色体的断裂突变子和一个受精后不久在卵细胞中起作用的抑制子。这些成分的传递是通过来自母鸡正反交后代的反复回交杂交雌性后代产生的微小突变频率来监测的。通过这种方式，突变子被证明是一种染色体外传播的元件，其繁殖依赖于核基因。抑制能力被发现是由核基因决定的，其中一些基因是在延迟几代后才表达出来的。突变子和它的抑制者似乎都不具有传染性。对优势致死频率的测量表明，抑制子在修复突变子诱导的突变前损伤方面是完全有效的。将该突变-抑制系统的特性与果蝇杂交发育不全的特性进行了比较。
A partially characterized mutator-suppressor system, previously identified in theca;stwstock ofDrosophila ananassae, was shown to exist in thecaancestral stock; it consists of a clastogenic mutator of sperm chromosomes and a supressor that functions in the oöcyte soon after fertilization. Transmission of these components was monitored by Minute mutation frequencies produced by the progeny of recurrently backcrossed hybrid females derived from reciprocal outcrosses of thecastock. In this way, the mutator was shown to be an extrachromosomally transmitted element whose propagation depends upon nuclear genes. Suppressivity was found to be determined by nuclear genes, some of which are expressed only after a delay of several generations. Neither the mutator nor its suppressor appear to be infectious. Measurement of dominant lethal frequencies showed that the suppressor is completely effective in repair of premutational lesions induced by the mutator. The properties of this mutator-suppressor system were compared with those of hybrid dysgenesis inDrosophila melanogaster.