Effect of resource availability on biparental care, and offspring neural and behavioral development in the California mouse (Peromyscus californicus)
Effect of resource availability on biparental care, and offspring neural and behavioral development in the California mouse (Peromyscus californicus)
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DOI：
10.1111/j.1460-9568.2006.05266.x
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发表时间：
2007-01-01
影响因子：
3.4
通讯作者：
Meaney, Michael J.
中科院分区：
文献类型：
--
作者：
Bredy, Timothy W.;Brown, Richard E.;Meaney, Michael J.
母亲照顾影响人类、灵长类动物和啮齿类动物的认知功能;然而，对双亲照顾的影响知之甚少。环境因素，如资源的可用性在调节父母的投资策略，随后对后代的影响发挥了重要作用。因此，我们研究了觅食需求和双亲照顾海马发育和新的物体识别在一夫一妻制，双亲加州小鼠之间的相互作用。我们的特点是双亲行为的家庭暴露于控制（随意喂养）或高觅食的需求在整个断奶期15天。成年雄性后代，然后在开放领域进行测试，并为新的物体和位置的识别，以及海马突触密度和编码亚基的N-甲基-D-天冬氨酸（NMDA）受体复合物的基因的表达，和突触后密度（PSD）-95支架蛋白。在高觅食需求下，母亲的体重在断奶时下降，父亲与幼崽接触的时间显着减少。在高觅食需求下饲养的后代在断奶时体重较轻，成年后在开阔的田野中更加恐惧，在新物体和地点识别方面表现出严重的缺陷。虽然突触密度和NR 1 mRNA表达不受影响，但在高觅食需求下饲养的后代显示NR 2A mRNA表达增加，NR 2B mRNA表达减少。此外，PSD-95蛋白表达在高觅食需求下饲养的小鼠中降低。总之，研究结果表明，资源的可用性影响双亲的投资策略，随后影响海马的发展和新的物体识别的后代。
Maternal care influences cognitive function in humans, primates and rodents; however, little is known about the effect of biparental care. Environmental factors such as resource availability play an important role in modulating parental investment strategies with subsequent effects on the offspring. Thus, we examined the interaction between foraging demand and biparental care on hippocampal development and novel object recognition in the monogamous, biparental California mouse. We characterized biparental behavior for 15 days in families exposed to either control (ad libitum feeding) or a high-foraging demand across the weaning period. Adult male offspring were then tested in the open field, and for novel object and place recognition, as well as for hippocampal synaptic density and the expression of genes encoding for subunits of the N-methyl-D-aspartate (NMDA) receptor complex, and the postsynaptic density (PSD)-95 scaffolding protein. Under high-foraging demand, the mothers' body weight was decreased at weaning and fathers spent significantly less time in contact with pups. Offspring reared under high-foraging demand weighed less at weaning and, as adults, were more fearful in the open field and showed profound deficits in both novel object and place recognition. While synaptic density and NR1 mRNA expression were unaffected, offspring reared under high-foraging demand showed increased NR2A and decreased NR2B mRNA expression. Further, PSD-95 protein expression was decreased in mice reared under high-foraging demand. Together, the results suggest that resource availability affects biparental investment strategies, with subsequent effects on hippocampal development and novel object recognition in the offspring.