Effects of iron-deficiency anemia on cadmium uptake or kidney dysfunction are essentially nil among women in general population in Japan.
Effects of iron-deficiency anemia on cadmium uptake or kidney dysfunction are essentially nil among women in general population in Japan.
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在日本普通人群中，缺铁性贫血对镉吸收或肾功能障碍的影响基本上为零。
DOI：
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发表时间：
2002
影响因子：
2.2
通讯作者：
M. Ikeda
中科院分区：
文献类型：
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作者：
T. Tsukahara;T. Ezaki;J. Moriguchi;K. Furuki;H. Ukai;S. Okamoto;H. Sakurai;M. Ikeda
在本研究中，日本6个县的1476名成年女性自愿提供外周血和尿样，并填写社会习惯和健康问卷。分析血样中的铁、铁蛋白和TIBC，以及全血中的红细胞、血红蛋白和Cd。分析尿样中Cd、α - 1- mg和β - 2- mg的含量；对肌酐进行校正，表示为Cd-Ucr。在1212名从不吸烟的女性中，37名血清铁蛋白< 25 ng/ml，血Hb < 10 g/100 ml的女性被归类为贫血，而701名铁蛋白= 25 ng/ml，血Hb = 10 g/100 ml的女性被归类为对照组。34例贫血患者按年龄和居住地匹配成功。比较（配对t检验）血液中的Cd和尿中的Cd， α - 1- mg和β - 2- mg（校正肌酐）与匹配对照没有显著差异。因此，在日本普通女性人群中，目前的铁缺乏水平可能不会导致Cd吸收或Cd相关肾功能障碍的显著增加。
In the present study, 1476 adult women in 6 prefectures in Japan volunteered to offer peripheral blood and spot urine samples, and to complete questionnaires on social habits and health. Blood samples were analyzed for iron, ferritin and TIBC in serum in addition to RBC, Hb and Cd in whole blood. Urine samples were analyzed for Cd, alpha1-MG, and beta2-MG; the measures were corrected for creatinine and were expressed as e.g., Cd-Ucr. Among 1212 never-smokers, 37 women with < 25 ng ferritin/ml serum and < 10 g Hb/100 ml blood were classified as the anemics, whereas 701 women with > or = 25 ng/ml ferritin and > or = 10 g/100 ml Hb were taken as controls. Matching by age and the prefecture of residence was successful for 34 anemics. Comparison (by paired t-test) of Cd in blood, and Cd, alpha1-MG and beta2-MG in urine (as corrected for creatinine) of the anemics with that of matched controls showed no significant differences. Thus, it appeared likely that the current level of iron insufficiency among general women population in Japan may not induce substantial increase in Cd absorption or Cd-associated kidney dysfunction.