ALKALOIDS FROM PSYCHOTRIA-OLEOIDES WITH ACTIVITY ON GROWTH-HORMONE RELEASE
ALKALOIDS FROM PSYCHOTRIA-OLEOIDES WITH ACTIVITY ON GROWTH-HORMONE RELEASE
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DOI：
10.1021/np50085a012
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发表时间：
1992-07-01
影响因子：
5.1
通讯作者：
POTIER, P
中科院分区：
文献类型：
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作者：
GUERITTEVOEGELEIN, F;SEVENET, T;POTIER, P
以生物活性为导向，分离纯化了一种新型生物碱：灵油碱[1]和四聚吡咯烷二吲哚碱化合物四聚胺C[2]。通过对四叉二胺C和三聚吡咯烷二吲哚碱物质hodgkinsin[3]的nmr和cd谱的比较研究，我们提出了四叉二胺C的立体化学性质。通过光谱方法和与四叉二胺C的化学相关性确定了四叉二胺的结构和构型。
Bioactivity-guided purification of a crude alkaloid extract of Psychotria oleoides has afforded a new alkaloid, psycholeine [1], together with quadrigemine C [2], a tetrameric pyrrolidinoindoline compound of unknown stereochemistry. A comparison study of nmr and cd spectra of quadrigemine C and hodgkinsine [3], a trimeric pyrrolidinoindoline substance, led us to suggest the stereochemistry of quadrigemine C. The structure and configuration of psycholeine was determined by spectroscopic means and chemical correlation with quadrigemine C. Psycholeine interacts with somatostatin receptors and exhibits a somatostatin antagonistic activity on GH secretion by pituitary cells in primary culture.