A complete shikimate pathway in Toxoplasma gondii:: an ancient eukaryotic innovation
A complete shikimate pathway in Toxoplasma gondii:: an ancient eukaryotic innovation
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DOI：
10.1016/j.ijpara.2003.10.006
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发表时间：
2004-01-01
影响因子：
4
通讯作者：
Roberts, CW
中科院分区：
文献类型：
--
作者：
Campbell, SA;Richards, TA;Roberts, CW
莽草酸途径对于顶复门寄生虫恶性疟原虫、刚地弓形虫和微小隐孢子虫的存活是必不可少的。由于它在哺乳动物中不存在，因此它是一个有前途的治疗靶点。在此，我们描述了编码T.刚地。蛋白质的分子排列和同源性表明与真核真菌酶同源，包括五功能AROM。目前的真核生物进化树的根推断真菌和apicomplexan谱系分歧很大，这表明arom是一个古老的超基因存在于早期真核生物中，随后丢失或取代了一些谱系。(C)2003年代表澳大利亚寄生虫学会由爱思唯尔有限公司出版。保留所有权利。
The shikimate pathway is essential for survival of the apicomplexan parasites Plasmodium falciparum, Toxoplasma gondii and Cryptosporidium parvum. As it is absent in mammals it is a promising therapeutic target. Herein, we describe the genes encoding the shikimate pathway enzymes in T. gondii. The molecular arrangement and phylogeny of the proteins suggests homology with the eukaryotic fungal enzymes, including a pentafunctional AROM. Current rooting of the eukaryotic evolutionary tree infers that the fungi and apicomplexan lineages diverged deeply, suggesting that the arom is an ancient supergene present in early eukaryotes and subsequently lost or replaced in a number of lineages. (C) 2003 on behalf of Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.