6 Chemoenzymatic Dynamic Kinetic Resolution of Alcohols
6 Chemoenzymatic Dynamic Kinetic Resolution of Alcohols
复制标题
6 醇的化学酶动态动力学拆分
DOI：
10.1055/sos-sd-237-00069
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Akai S.
中科院分区：
文献类型：
--
作者：
Kanomata K.;Akai S.
< jats: title> 摘要< jats: p> 化学酶动态动力学拆分是从外消旋体中获得光学纯醇衍生物的最简单、最可靠的方法之一。为此，水解酶特别是脂肪酶已广泛应用于对映选择性酯化过程，并开发了多种具有高催化效率且与脂肪酶相容的外消旋化催化剂。本综述介绍了基于外消旋催化剂类别的醇的化学酶 DKR。还讨论了轴向手性羟基联芳基的 DKR 和使用工程脂肪酶获得相反的对映体，以及 DKR 产品的合成应用。
< jats: title> Abstract< jats: p> Chemoenzymatic dynamic kinetic resolution is one of the simplest and most reliable methods to obtain optically pure alcohol derivatives from racemates. For this purpose, hydrolases, especially lipases, have been widely used in the enantioselective esterification processes, and a variety of racemization catalysts with high catalytic efficiency and compatibility with lipases have been developed. This review introduces chemoenzymatic DKR of alcohols based on the category of racemization catalysts. DKR of axially chiral hydroxybiaryls and the use of engineered lipases to obtain opposite enantiomers, as well as the synthetic applications of the DKR products, are also discussed.