Type 2 Diabetes and Late-Onset Alzheimer's Disease
Type 2 Diabetes and Late-Onset Alzheimer's Disease
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DOI：
10.1159/000324134
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发表时间：
2011-01-01
影响因子：
2.4
通讯作者：
Luchsinger, J. A.
中科院分区：
文献类型：
--
作者：
Cheng, D.;Noble, J.;Luchsinger, J. A.
背景/目的：为了在 19992001 年招募的队列中证实我们在 1992-1994 年招募的队列中的发现，将 2 型糖尿病 (T2D) 与迟发性阿尔茨海默病 (LOAD) 联系起来。方法：参与者为来自纽约市的 1,488 名 65 岁及以上基线时无痴呆症的人。 T2D 通过自我报告确定。痴呆症和 LOAD 通过标准研究程序确定。比例风险回归用于与 T2D 和 LOAD 相关的分析。结果：T2D 患病率为 17%。其中有 161 例患有痴呆症，149 例患有 LOAD。调整年龄、性别、教育程度、种族和载脂蛋白 E epsilon 4 后，T2D 与痴呆（风险比 = 1.7；95% 置信区间 = 1.4-2.9）和 LOAD（1.6；1.0-2.6）相关。当仅考虑 AD（排除混合性痴呆病例）时，这种关联性较弱（风险比 = 1.3；95% 置信区间 = 0.8-2.2）。结论：T2D 与 LOAD 相关。脑血管疾病可能是一个重要的介质。版权所有 (C) 2011 S. Karger AG，巴塞尔
Background/Aims: To confirm in a cohort recruited in 19992001 our finding in a cohort recruited in 1992-1994 relating type 2 diabetes (T2D) to late-onset Alzheimer's disease (LOAD). Methods: Participants were 1,488 persons aged 65 years and older without dementia at baseline from New York City. T2D was ascertained by self-report. Dementia and LOAD were ascertained by standard research procedures. Proportional hazard regression was used for analyses relating T2D and LOAD. Results: The prevalence of T2D was 17%. There were 161 cases of dementia and 149 cases of LOAD. T2D was related to dementia (hazard ratio = 1.7; 95% confidence interval = 1.4-2.9) and LOAD (1.6; 1.0-2.6) after adjustment for age, sex, education, ethnic group and apolipoprotein E epsilon 4. This association was weaker when only AD - excluding cases of mixed dementia - was considered (hazard ratio = 1.3; 95% confidence interval = 0.8-2.2). Conclusion: T2D is associated with LOAD. Cerebrovascular disease may be an important mediator. Copyright (C) 2011 S. Karger AG, Basel