Correlation between auto/mitophagic processes and magnetic resonance imaging activity in multiple sclerosis patients
Correlation between auto/mitophagic processes and magnetic resonance imaging activity in multiple sclerosis patients
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DOI：
10.1186/s12974-019-1526-0
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发表时间：
2019-06-27
影响因子：
9.3
通讯作者：
Pinton, Paolo
中科院分区：
文献类型：
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作者：
Castellazzi, Massimiliano;Patergnani, Simone;Pinton, Paolo
目的探讨自噬相关蛋白5(ATG5)和有丝分裂相关蛋白(Parkin)分别作为自噬和有丝分裂相关蛋白在MS患者中的表达水平和乳酸水平。方法对60例MS患者的脑脊液(CSF)和血清标本进行分析，其中30例有疾病活动的磁共振成像(MRI)证据，30例Gd造影剂阳性(Gd+)，30例无MRI疾病活动证据(Gd-)。结果与结论Gd+患者血清ATG5、Parkin和乳酸水平明显高于Gd-MS患者(P
BackgroundAn alteration of autophagy and mitophagy, two highly conserved lysosome-dependent degradation pathways involved in the maintenance of cellular homeostasis, has been associated with multiple sclerosis (MS).ObjectiveTo search the level of autophagy-related 5 (ATG5) and Parkin proteins, as markers of autophagy and mitophagy respectively, and lactate in a cohort of MS patients.MethodsCerebrospinal fluid (CSF) and serum samples from 60 MS patients were analyzed: 30 with magnetic resonance imaging (MRI) evidence of disease activity, gadolinium (Gd)-based contrast agent positive (Gd+), and 30 without MRI evidence of disease activity (Gd-). ATG5, Parkin, and lactate were measured using commercially available products.Results and conclusionsSerum levels of ATG5, Parkin, and lactate were more elevated in Gd+ than in Gd- MS patients (p