INVOLVEMENT OF M-CELLS IN THE BACTERIAL INVASION OF PEYER PATCHES - A COMMON MECHANISM SHARED BY YERSINIA-ENTEROCOLITICA AND OTHER ENTEROINVASIVE BACTERIA
INVOLVEMENT OF M-CELLS IN THE BACTERIAL INVASION OF PEYER PATCHES - A COMMON MECHANISM SHARED BY YERSINIA-ENTEROCOLITICA AND OTHER ENTEROINVASIVE BACTERIA
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DOI：
10.1136/gut.31.9.1011
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发表时间：
1990-09-01
期刊：
影响因子：
24.5
通讯作者：
RIECKEN, EO
中科院分区：
文献类型：
--
作者：
GRUTZKAU, A;HANSKI, C;RIECKEN, EO
最近的证据表明，回肠Peyer‘s斑块是小肠结肠炎耶尔森菌的主要感染途径。在这项研究中，透射和扫描电子显微镜显示，管腔中只有一小部分细菌附着在毛囊相关的小鼠上皮上，对M细胞或吸收细胞没有明显的偏好。附着在M细胞上的耶尔森氏杆菌被吞噬，并从管腔进入固有层。未见柱状吸收细胞侵袭。这些数据，结合最近发表的报告，表明M细胞的参与是细菌入侵Peyer‘s斑块的常见步骤。
Recent evidence indicates that ileal Peyer's patches represent the main infection route for Yersinia enterocolitica. In this study transmission and scanning electron microscopy have shown that only a small fraction of bacteria present in the lumen adhere to the follicle-associated murine epithelium with no discernible preference for either M or absorptive cells. Yersiniae attached to M cells are phagocytosed and transported from the lumen into the lamina propria. No invasion of columnar absorptive cells was observed. These data, in combination with recently published reports, indicate that the involvement of M cells is a common step in bacterial invasion of Peyer's patches.