Superparamagnetic Nanoparticle-Supported (S)-Diphenyl- prolinol Trimethylsilyl Ether as a Recyclable Catalyst for Asymmetric Michael Addition in Water
Superparamagnetic Nanoparticle-Supported (S)-Diphenyl- prolinol Trimethylsilyl Ether as a Recyclable Catalyst for Asymmetric Michael Addition in Water
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DOI：
10.1002/adsc.201000508
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发表时间：
2010-11
影响因子：
5.4
通讯作者：
B. Wang;B. Ma;Qiong Wang;Wen Wang
中科院分区：
文献类型：
--
作者：
B. Wang;B. Ma;Qiong Wang;Wen Wang
A new superparamagnetic nanoparticle- supported (S)-diphenylprolinol trimethylsilyl ether (Jorgensen-Hayashi catalyst) was synthesized and applied for the asymmetric Michael addition of al- dehydes to nitroalkenes in water, which gives prod- ucts in moderate to good yields (up to 96%), good enantioselectivity (up to 90% ee) and diastereose- lectivities (up to 99:1). The immobilized catalyst could be easily separated from the reaction by an external magnet and recycled for four times without significant loss of catalytic efficiency.
