The origin and role of innate lymphoid cells in the lung.
The origin and role of innate lymphoid cells in the lung.
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DOI：
10.1186/s40779-016-0093-2
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发表时间：
2016
影响因子：
21.1
通讯作者：
Fan J
中科院分区：
文献类型：
--
作者：
Lai DM;Shu Q;Fan J
先天淋巴细胞（Innate lymphoid cells, ILCs）是淋巴细胞群中一个新发现的成员，在宿主防御中从先天免疫到适应性免疫的转变中起着关键作用。白细胞介素在粘膜屏障免疫、组织稳态和全身免疫调节中起重要作用。肺部疾病中ILC反应的显著改变已被观察和报道。新出现的证据表明，ilc在多种肺部疾病的发病和发展中起重要作用，如蠕虫感染、过敏性气道炎症和气道超反应性。然而，作为一种组织驻留细胞群，ilc在肺中的作用仍然缺乏表征。在这篇综述中，我们讨论了ILC在肺部疾病中的作用，ILC介导的免疫调节机制，以及调节ILC反应的治疗潜力。
Innate lymphoid cells (ILCs), a newly identified member of the lymphoid population, play a critical role in the transition from innate to adaptive immunity in host defense. ILCs are important in mucosal barrier immunity, tissue homeostasis, and immune regulation throughout the body. Significant alterations in ILC responses in lung diseases have been observed and reported. Emerging evidence has shown that ILCs are importantly involved in the pathogenesis and development of a variety of lung diseases, i.e., helminth infections, allergic airway inflammation, and airway hyper-responsiveness. However, as a tissue-resident cell population, the role of ILCs in the lung remains poorly characterized. In this review, we discuss the role of ILCs in lung diseases, the mechanisms underlying the ILC-mediated regulation of immunity, and the therapeutic potential of modulating ILC responses.