Duration of hormonal replacement therapy in general practice; a follow-up study.
Duration of hormonal replacement therapy in general practice; a follow-up study.
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一般实践中激素替代疗法的持续时间；
DOI：
10.1016/s0378-5122(98)00016-4
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发表时间：
1998
期刊：
影响因子：
4.9
通讯作者：
A. Hoes
中科院分区：
文献类型：
--
作者：
F. Groeneveld;F. Bareman;R. Barentsen;H. Dokter;A. Drogendijk;A. Hoes
目的评估一般情况下HRT使用的平均持续时间，并确定HRT使用时间的决定因素。方法对5个全科医生分组就诊的1689名45-60岁的普通人群进行9个月的随访，追踪首次HRT处方。103名接受激素替代疗法的妇女被随访了2.25年。HRT的持续时间通过使用提供的HRT分配数据进行评估。使用时间的可能决定因素，如对更年期的态度，更年期状况和其他六个变量通过问卷调查的方式进行测量。结果103名妇女中没有人接受激素替代疗法以预防目的；主要的适应症是更年期症状。超过60%的女性在6个月内停止了激素替代疗法，只有8%的女性继续接受激素替代疗法超过2年。平均使用时间为7个月。预测HRT使用持续时间的决定因素是年龄，对更年期治疗的态度和团体实践。结论HRT的平均使用时间很短，尽管最普遍的适应症是缓解更年期症状。显然，荷兰女性目前不愿意长时间接受激素替代疗法。
ObjectivesTo assess the mean duration of use of HRT in general practice and to identify determinants of the duration of HRT use.MethodsA general population of 1689 women aged 45–60 years and enlisted in five group practices of general practitioners were followed for 9 months to trace first HRT prescriptions. All 103 women who were prescribed HRT were followed for a period of 2.25 years. Duration of HRT was assessed by using the data provided on the dispensing of HRT. Possible determinants of duration of use, such as attitude towards menopause, menopausal status and another six variables were measured by means of a questionnaire.ResultsNone of the 103 women received HRT for a preventive purpose; the main indication was menopausal complaints. More than 60% of the women stopped their HRT within 6 months and only 8% of the women remained on HRT for more than 2 years. The mean duration of use was 7 months. Determinants that significantly predicted the duration of HRT use were age, attitude towards treatment of the menopause and the group practice.ConclusionsThe mean duration of HRT use is very short, despite the fact that the most prevalent indication is the alleviation of menopausal symptoms. Apparently, Dutch women are presently unwilling to take HRT for longer periods.
DOI：
10.1097/00006254-199202000-00027
发表时间：
1991-09
期刊：
The New England journal of medicine
影响因子：
--
作者：
M. Stampfer;G. Colditz;W. Willett;J. Manson;B. Rosner;F. Speizer;C. Hennekens
通讯作者：
M. Stampfer;G. Colditz;W. Willett;J. Manson;B. Rosner;F. Speizer;C. Hennekens
影响因子：
12.7
作者：
Harris,RB;Laws,A;Reddy,VM;King,A;Haskell,WL
通讯作者：
Haskell,WL