Short-term changes in serum leptin levels provide a strong metabolic marker for the growth response to growth hormone treatment in children
Short-term changes in serum leptin levels provide a strong metabolic marker for the growth response to growth hormone treatment in children
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DOI：
10.1210/jc.83.8.2735
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发表时间：
1998-08-01
影响因子：
5.8
通讯作者：
Albertsson-Wikland, K
中科院分区：
文献类型：
--
作者：
Kriström, B;Carlsson, B;Albertsson-Wikland, K
生长反应生长激素治疗不同的儿童。除了调节纵向生长，GH发挥重要的代谢作用，包括脂解。在这项研究中，我们检查是否GH诱导的血清中的脂肪组织源性激素瘦素水平的变化可以作为一个标志物的长期生长反应GH治疗青春期前儿童短。研究组由150名儿童（21名女孩和129名男孩）组成，他们在GH治疗开始时年龄为3 - 15岁，最大GH分泌能力从很低到很高。他们接受GH（0.1 IU/www.example.com）治疗，并随访至少1年。第一年身高SD评分平均增加0.79（sD，0.34），范围很广（0.08 - 2.27）。GH治疗1、3和12个月后，血清瘦素浓度与治疗开始时的水平相比显著降低。生长反应与治疗开始时的血清瘦素浓度相关（r = 0.49; P <0.0001），与治疗1个月（r =-0.41; P <0.01）和3个月（r =-0.60; P <0.0001）后血清瘦素浓度的变化相关。当应用多元逐步回归分析与生长激素治疗的第一年生长反应相关（P <0.10）的生长学和生化变量时，血清瘦素浓度的3个月变化是解释个体生长反应差异的最重要变量。我们的结论是，瘦素水平在GH治疗开始以及瘦素水平的短期变化，在GH治疗是有价值的长期生长反应的标志。
The growth response to GH treatment varies between children. Besides regulating longitudinal growth, GH exerts important metabolic effects, including lipolysis. In this study we examined whether GH-induced changes in serum levels of the adipose tissue-derived hormone leptin can be used as a marker for the long term growth response to GH treatment in short prepubertal children. The study group consisted of 150 children (21 girls and 129 boys), who were 3-15 yr of age at the start of GH treatment and had a maximum GH secretory capacity ranging from very low to high. They were treated with GH (0.1 IU/kg.day) and followed for at least 1 yr.The first year mean increase in height SD score was 0.79 (sD, 0.34), with a broad range (0.08-2.27). Serum leptin concentrations were significantly reduced after 1, 3, and 12 months of GH treatment compared with levels at the start of treatment. The growth response correlated with the serum leptin concentration at the start of treatment (r = 0.49; P < 0.0001) and with the change in serum leptin concentration after both 1 month (r = -0.41; P < 0.01) and 3 months (r = -0.60; P < 0.0001) of treatment. When multiple stepwise regression analysis was applied to the auxological and biochemical variables that correlated (P < 0.10) with the first year growth response to GH treatment, the 3-month change in serum leptin concentration was the single most important variable for explaining the variance in individual growth responses. We conclude that leptin levels at the start of GH treatment as well as short term changes in leptin levels in response to GH treatment are valuable markers of the long term growth response.