Cognitive deficits in Huntington's disease are predicted by dopaminergic PET markers and brain volumes
Cognitive deficits in Huntington's disease are predicted by dopaminergic PET markers and brain volumes
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DOI：
10.1093/brain/120.12.2207
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发表时间：
1997-12-01
期刊：
影响因子：
14.5
通讯作者：
Farde, L
中科院分区：
文献类型：
--
作者：
Bäckman, L;Robins-Wahlin, TB;Farde, L
本研究的主要目的是调查多巴胺能标记物和纹状体和皮质结构的脑容量之间的关系，以及亨廷顿病患者和对照组的认知表现。我们将PET和MRI数据作为评估执行功能、视觉空间能力、情景记忆、语言流畅性、感知速度和推理的任务中的表现的预测因子。多巴胺神经传递参数（D-1和D-2受体密度和多巴胺转运蛋白密度）和尾状核和壳核的体积测量值占大多数认知任务方差的很大一部分。此外，额叶体积与所有认知任务都有很强的相关性。对颞叶皮层和丘脑体积的Dr结合和体积测量显示出与一些特定的认知任务有关。总体数据模式与以下观点一致，即亨廷顿病可被表征为额纹状体痴呆，其中认知缺陷可由额纹状体回路中多个部位的病理变化引起。
The main aim of this study was to investigate the relationship between dopaminergic markers and brain volumes for striatal and cortical structures, and cognitive performance in patients with Huntington's disease and control subjects. We wed PET and MRI data as predictors of performance in tasks assessing executive function, visuospatial ability episodic memory, verbal fluency perceptual speed and reasoning. The dopamine neurotransmission parameters (D-1 and D-2 receptor density and dopamine transporter density) and the volumetric measurements for caudate and putamen accounted for substantial portions of the variance across the majority of cognitive tasks. In addition, frontal volume showed a strong relationship with all cognitive tasks. Dr binding and volume measurements for the temporal cortex and thalamic volume showed associations with a select number of cognitive tasks. The overall data pattern is consistent with the view that Huntington's disease may be characterized as a frontostriatal dementia, in which cognitive deficits may result from pathological changes at multiple sites in the frontostriatal circuitry.