Peroxisome proliferator-activated receptor alpha-independent peroxisome proliferation.
Peroxisome proliferator-activated receptor alpha-independent peroxisome proliferation.
复制标题
过氧化物酶体增殖物激活受体α不依赖的过氧化物酶体增殖。
DOI：
10.1016/j.bbrc.2006.06.042
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发表时间：
2006
影响因子：
3.1
通讯作者：
Aoyama,Toshifumi
中科院分区：
文献类型：
--
作者：
Zhang,Xiuguo;Tanaka,Naoki;Nakajima,Takero;Kamijo,Yuji;Gonzalez,FrankJ;Aoyama,Toshifumi
肝脏过氧化物酶体增殖，即过氧化物酶体数量和体积密度的增加，被认为与过氧化物酶体增殖物激活受体α（过氧化物酶体增殖物激活受体α）的激活密切相关;然而，过氧化物酶体增殖是否完全依赖于这种激活仍然未知。为了验证非PPARα依赖性过氧化物酶体增殖的发生，使用了非诺贝特处理，预期其可显著增强试验系统中的PPARα依赖性。令人惊讶的是，在PPARα-null小鼠中发现了一种新型的不依赖于PPARα的过氧化物酶体增殖和扩大。动力蛋白样蛋白1的表达增加，而过氧化物酶体生物合成因子11α的表达增加，可能与过氧化物酶体增殖无关。
Hepatic peroxisome proliferation, increases in the numerical and volume density of peroxisomes, is believed to be closely related to peroxisome proliferator-activated receptor α (PPARα) activation; however, it remains unknown whether peroxisome proliferation depends absolutely on this activation. To verify occurrence of PPARα-independent peroxisome proliferation, fenofibrate treatment was used, which was expected to significantly enhance PPARα dependence in the assay system. Surprisingly, a novel type of PPARα-independent peroxisome proliferation and enlargement was uncovered in PPARα-null mice. The increased expression of dynamin-like protein 1, but not peroxisome biogenesis factor 11α, might be associated with the PPARα-independent peroxisome proliferation at least in part.