Influenza A virus is transmissible via aerosolized fomites
Influenza A virus is transmissible via aerosolized fomites
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DOI：
10.1038/s41467-020-17888-w
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发表时间：
2020-08-18
影响因子：
16.6
通讯作者：
Bouvier, Nicole M.
中科院分区：
文献类型：
--
作者：
Asadi, Sima;Ben Hnia, Nassima Gaaloul;Bouvier, Nicole M.
据推测，流感病毒通过几种可能的途径在人类中传播，但尚未得出结论。我们提供了一种很少被认为是流感的传播方式的证据：通过称为“气溶胶污染物”的微观颗粒进行空气传播的病毒。“在流感病毒传播的豚鼠模型中，我们发现受感染动物产生的空气颗粒主要是非呼吸源的。令人惊讶的是，我们发现一只未感染的、对病毒免疫的豚鼠，其身体被流感病毒污染，可以通过空气将病毒传播给单独笼子里的易感伴侣。我们进一步证明，气溶胶污染物可以从无生命的物体产生，例如通过手动摩擦被流感病毒污染的纸巾。我们的数据表明，气溶胶污染物可能有助于流感病毒在人类流感动物模型中的传播，如果不是在人类之间传播的话，这对公共卫生具有重要但尚未充分研究的意义。
Influenza viruses are presumed, but not conclusively known, to spread among humans by several possible routes. We provide evidence of a mode of transmission seldom considered for influenza: airborne virus transport on microscopic particles called "aerosolized fomites." In the guinea pig model of influenza virus transmission, we show that the airborne particulates produced by infected animals are mainly non-respiratory in origin. Surprisingly, we find that an uninfected, virus-immune guinea pig whose body is contaminated with influenza virus can transmit the virus through the air to a susceptible partner in a separate cage. We further demonstrate that aerosolized fomites can be generated from inanimate objects, such as by manually rubbing a paper tissue contaminated with influenza virus. Our data suggest that aerosolized fomites may contribute to influenza virus transmission in animal models of human influenza, if not among humans themselves, with important but understudied implications for public health.