The Association between Prenatal Yoga and the Administration of Ritodrine Hydrochloride during Pregnancy: An Adjunct Study of the Japan Environment and Children's Study.
The Association between Prenatal Yoga and the Administration of Ritodrine Hydrochloride during Pregnancy: An Adjunct Study of the Japan Environment and Children's Study.
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DOI：
10.1371/journal.pone.0158155
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Kishi R
中科院分区：
文献类型：
--
作者：
Kawanishi Y;Saijo Y;Yoshioka E;Nakagi Y;Yoshida T;Miyamoto T;Sengoku K;Ito Y;Miyashita C;Araki A;Kishi R
虽然产前瑜伽的有益效果近年来已被报道，但对日本孕妇的有效性知之甚少。尽管有一些不良反应，盐酸利托君在日本经常被用于抑制早产，因此其使用可能提示早产病例。本研究旨在阐明产前瑜伽和盐酸利托君在怀孕期间使用之间的关联。日本环境和儿童研究的北海道单位进行了一项观察性研究，作为一项辅助研究。在2012年3月21日至2015年7月7日期间，使用自我问卷收集了有关产前瑜伽练习的信息，针对最近分娩的女性。从医疗记录中确定了盐酸利托君的使用。共2,692名妇女进行了分析，使用逻辑回归模型，调整可能的混杂因素。有567名（21.1%）妇女在产前练习瑜伽，这与使用盐酸利托君的风险较低有关（调整后的比值比[OR] 0.77; 95%CI 0.61-0.98）。这在整个妊娠期间总练习时间超过900分钟的女性中尤其明显（调整后OR 0.54; 95% CI 0.38-0.76）。一项敏感性分析排除了研究期间先兆流产的患者，得出了类似的结果。产前瑜伽与盐酸利托君使用风险较低相关，特别是在怀孕期间练习时间超过900分钟的女性中。产前瑜伽可能是孕妇在选择替代疗法时的一个有益选择。
While the beneficial effects of prenatal yoga have been reported in recent years, little is known about its effectiveness in pregnant Japanese women. Despite several adverse effects, ritodrine hydrochloride is frequently prescribed to suppress preterm labor in Japan, and its usage may therefore indicate cases of preterm labor. This study aimed to clarify the association between prenatal yoga and ritodrine hydrochloride use during pregnancy. An observational study was conducted as an adjunct study by the Hokkaido unit of the Japan Environment and Children’s Study. Information on prenatal yoga practice was collected using a self-questionnaire between March 21, 2012, and July 7, 2015, targeting women who had recently delivered. Ritodrine hydrochloride use was identified from medical records. A total of 2,692 women were analyzed using logistic regression models that adjusted for possible confounders. There were 567 (21.1%) women who practiced prenatal yoga, which was associated with a lower risk of ritodrine hydrochloride use (adjusted odds ratio [OR] 0.77; 95% CI 0.61–0.98). This was especially evident in women with a total practice duration that exceeded 900 minutes throughout their pregnancy (adjusted OR 0.54; 95% CI 0.38–0.76). A sensitivity analysis that excluded patients with threatened abortion during the study period produced similar results. Prenatal yoga was associated with a lower risk of ritodrine hydrochloride use, particularly in women with more than 900 minutes of practice time over the course of their pregnancy. Prenatal yoga may be a beneficial option for pregnant women in the selection of alternative therapies.