Finding Needles in the Gut Microbiota's Haystack.
Finding Needles in the Gut Microbiota's Haystack.
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DOI：
10.1161/circresaha.122.322354
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发表时间：
2023-01
影响因子：
20.1
通讯作者：
Michael Aljadah;Michael E. Widlansky
中科院分区：
文献类型：
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作者：
Michael Aljadah;Michael E. Widlansky
尽管我们似乎最近才认识到肠道微生物区系与动脉粥样硬化性心血管疾病(ASCVD)之间的联系，但摄取有益微生物以改变肠道微生物区系并预防或治疗人类疾病的概念并不新鲜。罗马作家和哲学家普林尼的《长老的自然史》在公元77年左右首次出版，描述了使用发酵牛奶治疗肠道问题。1800多年后，诺贝尔奖获得者埃利·梅奇尼科夫提出，尽管生活条件更加恶劣，但保加利亚农民的寿命比保加利亚贵族要长，这是因为农民经常食用的酸奶中的乳酸菌(LactobacillusBulgaris)被观察到存在于结肠中。大约在同一时间，亨利·蒂西尔在母乳喂养的婴儿的肠道细菌中发现了一种双歧杆菌，这种细菌与减少胃肠道疾病有关。2.
Despite the seeming recency of our recognition of the connection between the gut microbiota and atherosclerotic cardiovascular disease (ASCVD), the concept of ingesting beneficial microbes to change the gut microbiota and prevent or treat human disease is not a new one. Roman author and philosopher Pliny the Elder’s Natural History, first published around the year 77, described the use of fermented milk to treat intestinal problems. Over 1800 years later, Nobel Prize winner Élie Mechnikov proposed that Bulgarian peasants were outliving Bulgarian nobility, despite harsher living conditions, due to lactic acid-producing bacteria (Lactobacillus bulgaris) in yogurt commonly consumed by the peasants that were observed to be present in the colon. 1 Around the same, Henri Tissier discovered a Bifidobacterium in the gut bacteria of infants who were breastfed that he associated with reduced gastrointestinal illness. 2