DEVELOPMENT OF A PORTABLE BLOOD POTASSIUM MONITORING DEVICE FOR DIALYSIS PATIENTS.
DEVELOPMENT OF A PORTABLE BLOOD POTASSIUM MONITORING DEVICE FOR DIALYSIS PATIENTS.
复制标题
开发用于透析患者的便携式血钾监测装置。
DOI：
10.1115/dmd2020-9066
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Atta,MohamedG
中科院分区：
文献类型：
--
作者：
Vora,Parth;Inserni,Miguel;Lai,Alan;Lapinski,MayaM;Wang,Justin;Kim,MinJae;Lee,Diane;Yu,Rebecca;Manbachi,Amir;Atta,MohamedG
在美国，大约有50万透析患者处于高钾血症的高风险中，这是一种血钾升高超过正常水平的情况。高钾血症是非常危险的，因为它可以导致严重的心脏并发症，如果不治疗。高钾血症可能是无声的或目前模糊的症状，直到这些并发症的发展，在这一点上，患者需要紧急医疗护理。然而，如果患者能够在家中测量自己的钾水平，他们可以在高钾血症达到危险阶段之前发现它，并寻求预防性医疗护理，以避免严重的并发症。因此，我们设计了一种新的设备，允许患者在家中测量他们的血钾水平。我们的解决方案的工作流程如下：（1）患者从手指穿刺中获取血液样本，（2）使用离子特异性电极（伊势）测量钾浓度，（3）设备显示他们的钾水平和基于高钾血症风险的推荐治疗方案。我们通过三个主要测试验证我们的解决方案。首先，我们的便携式伊势技术必须准确测量血液样本中的钾浓度。其次，必须找到适当的采血针参数（规格和深度），以尽量减少毛细血管血液样本中的溶血，以尽量减少假性升高的读数。第三，必须使用患者输入来评估器械的便携性和易用性，因为这些因素会影响患者的依从性。我们已经验证了使用便携式伊势技术测量钾的可行性，我们将继续为第二次和第三次测试收集数据。
Approximately 500,000 dialysis patients in America are at a high risk of hyperkalemia, a condition where blood potassium becomes elevated above normal levels. Hyperkalemia is extremely dangerous, as it can result in severe cardiac complications if untreated. Hyperkalemia may be silent or present vague symptoms until those complications develop, at which point patients require emergency medical care. However, if patients have the ability to measure their potassium levels at home, they could detect hyperkalemia before it reaches a dangerous stage, and seek preventative medical care to avoid severe complications.Therefore, we have designed a novel device allowing patients to measure their blood potassium levels at home. The workflow of our solution is as follows: (1) patients obtain a blood sample from a finger prick, (2) potassium concentration is measured with an ion specific electrode (ISE), and (3) the device displays their potassium levels and a recommended course of action based on their hyperkalemic risk.We validate our solution with three major tests. First, our portable ISE technology must accurately measure potassium concentration in blood samples. Second, appropriate lancet parameters (gauge and depth) to minimize hemolysis in capillary blood samples must be found to minimize falsely elevated readings. Third, device portability and ease of use must be evaluated using patient input, as these factors will affect patient compliance. We have validated the use of portable ISE technology to feasibly measure potassium, and we continue to collect data for our second and third tests.