The serum S100B concentration is age dependent.
The serum S100B concentration is age dependent.
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血清 S100B 浓度与年龄有关。
DOI：
10.1093/clinchem/48.6.950
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发表时间：
2002
影响因子：
9.3
通讯作者：
D. Souza
中科院分区：
文献类型：
--
作者：
L. Portela;A. Tort;D. V. Schaf;L. Ribeiro;D. Nora;R. Walz;L. Rotta;Cátia T Silva;J. Busnello;F. Kapczinski;C. Gonçalves;D. Souza
S100B是一种21 kDa的钙结合蛋白，主要由中枢神经系统(CNS)中的星形胶质细胞产生和释放，在那里它发挥着神经和神经胶质的作用(1)。一些研究已经探讨了S100B作为神经损伤的外周生化标志物的潜在作用，包括反应性胶质增生、星形细胞死亡和/或血脑屏障功能障碍[2]。据报道，在一些急性和慢性损伤中，脑脊液(CSF)和/或血清S100B增加，包括创伤性脑损伤(3例)、中风(4例)、阿尔茨海默病(5例)、精神分裂症(6例)、HTLV-I相关性脊髓病(7例)和系统性红斑狼疮(8例)。
以前的神经发育研究表明，S100B在哺乳动物中枢神经系统中的表达和分布随年龄的变化而变化，这可能与该蛋白在胎儿、成年期和衰老过程中不同脑区的不同作用有关[1](9)。此外，在健康人中，脑脊液中S100B的浓度随着年龄的增加而增加(10)。由于这些增加在男性中比女性更明显(11)，脑脊液中S100B的浓度可能与性别和年龄有关，这表明在脑脊液中S100B的研究中可能需要年龄和性别匹配的对照。为了确定成年人血浆S100B的通常浓度，Wiesmann等人。(12)测量了健康献血者的蛋白质，在18-65岁的个体中没有发现性别和年龄的差异，这与我们在之前的成年人研究中的发现是一致的。
然而，据我们所知，直到最近才确定儿童和青春期血液中S100B的浓度。本研究验证了不同年龄健康人的S100B血清浓度，范围从新生儿到成年人。
我们采集了19名健康足月新生儿(48小时龄)和25名4-16岁健康儿童的血液样本，这些儿童正在接受常规的临床和…检查。
S100B is a 21-kDa calcium-binding protein produced and released primarily by astrocytes in the central nervous system (CNS), where it exerts neurotropic and gliotropic actions (1). Several studies have investigated the potential role of S100B as a peripheral biochemical marker of neural injury, including reactive gliosis, astrocytic death, and/or blood-brain barrier dysfunction (2). Increased cerebrospinal fluid (CSF) and/or serum S100B has been reported in several acute and chronic injuries, including traumatic brain injury (3), stroke (4), Alzheimer disease (5), schizophrenia (6), HTLV-I-associated myelopathy (7), and systemic lupus erythematosus (8).
Previous neurodevelopmental studies have demonstrated age-related changes in S100B tissue expression and distribution in the CNS in mammals, which may be related to the different roles of this protein in distinct brain regions during the fetal period, adulthood, and aging (1)(9). Furthermore, S100B concentrations in CSF have been noted to increase with age in healthy individuals (10). Because these increases are more evident in men than women (11), S100B concentrations in CSF may be sex and age dependent, suggesting that age- and sex-matched controls may be necessary for studies of S100B in CSF. To determine the usual concentrations for plasma S100B in adults, Wiesmann et al. (12) measured the protein in healthy blood donors and found no differences with sex and age in individuals 18–65 years of age, in agreement with our findings in previous studies in adults (6)(7)(8).
To our knowledge, however, S100B concentrations in blood in childhood and adolescence were not established until recently. The present study was performed to verify S100B serum concentrations in healthy individuals of different ages, ranging from neonates to adults.
We collected blood samples from 19 healthy term neonates (<48 h of age) and from 25 healthy children 4–16 years of age undergoing routine clinical and …