A meta-analysis of cardiac electrophysiology computational models
A meta-analysis of cardiac electrophysiology computational models
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DOI：
10.1113/expphysiol.2008.044610
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发表时间：
2009-05-01
影响因子：
2.7
通讯作者：
Smith, N. P.
中科院分区：
文献类型：
--
作者：
Niederer, S. A.;Fink, M.;Smith, N. P.
心脏电生理学的计算模型是将多个数据集集成到一致的生物物理框架中的典型演示。这些模型封装了生理学的理解，以提供功能的定量预测。现有模型在一个共同框架内的组合或扩展允许对更大系统中的综合现象进行研究。正如越来越多使用或扩展以前开发的模型的研究所证明的那样，这种方法现在已被常规应用。在本研究中，我们以参数遗传树的形式对该模型重用的两种主要心脏电生理模型进行了荟萃分析，进行了敏感性分析，并比较了钠钾泵对定义恢复曲线的功能意义。这些结果表明，尽管这些模型旨在表征相同的生理系统，但参数值的来源和等效成分的功能都存在显著差异。
Computational models of cardiac electrophysiology are exemplar demonstrations of the integration of multiple data sets into a consistent biophysical framework. These models encapsulate physiological understanding to provide quantitative predictions of function. The combination or extension of existing models within a common framework allows integrative phenomena in larger systems to be investigated. This methodology is now routinely applied, as demonstrated by the increasing number of studies which use or extend previously developed models. In this study, we present a meta-analysis of this model re-use for two leading models of cardiac electrophysiology in the form of parameter inheritance trees, a sensitivity analysis and a comparison of the functional significance of the sodium potassium pump for defining restitution curves. These results indicate that even though the models aim to represent the same physiological system, both the sources of parameter values and the function of equivalent components are significantly different.