Multifunctional micellar nanomedicine for cancer therapy.
Multifunctional micellar nanomedicine for cancer therapy.
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DOI：
10.3181/0808-mr-250
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Gao J
中科院分区：
文献类型：
--
作者：
Blanco E;Kessinger CW;Sumer BD;Gao J
聚合物胶束是一种超分子核壳结构的纳米粒子，在癌症诊断和治疗中具有重要的应用价值。它们相对小的尺寸（10-100 nm）、溶解疏水性药物以及成像剂的能力以及改进的药代动力学为癌症应用提供了有用的生物工程平台。几种聚合物胶束制剂目前正在进行I/II期临床试验，这些试验已显示出改善的抗肿瘤功效和降低的全身毒性。本文将重点介绍具有肿瘤靶向、刺激药物释放和癌症成像功能的胶束纳米药物多功能设计的最新进展。这样的功能化策略导致在肿瘤部位的胶束积累增强，药物生物利用度更高，以及改善的肿瘤诊断和治疗的可视化。最终，集成纳米系统（例如，治疗诊断纳米医学）可能被证明对于解决肿瘤异质性和适应性抗性的挑战以实现癌症的有效治疗是必不可少的。
Polymeric micelles are supramolecular, core-shell nanoparticles that offer considerable advantages for cancer diagnosis and therapy. Their relatively small size (10-100 nm), ability to solubilize hydrophobic drugs as well as imaging agents, and improved pharmacokinetics provide a useful bioengineering platform for cancer applications. Several polymeric micelle formulations are currently undergoing phase I/II clinical trials, which have shown improved antitumor efficacy and reduced systemic toxicity. This minireview will focus on recent advancements in the multifunctional design of micellar nanomedicine with tumor targeting, stimulated drug release, and cancer imaging capabilities. Such functionalization strategies result in enhanced micellar accumulation at tumor sites, higher drug bioavailability, as well as improved tumor diagnosis and visualization of therapy. Ultimately, integrated nanotherapeutic systems (e.g., theranostic nanomedicine) may prove essential to address the challenges of tumor heterogeneity and adaptive resistance to achieve efficacious treatment of cancer.