Evidence for an Interaction Between Familial Liability and Prenatal Exposure to Infection in the Causation of Schizophrenia
Evidence for an Interaction Between Familial Liability and Prenatal Exposure to Infection in the Causation of Schizophrenia
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DOI：
10.1176/appi.ajp.2009.08010031
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发表时间：
2009-09-01
影响因子：
17.7
通讯作者：
Cannon, Mary
中科院分区：
文献类型：
--
作者：
Clarke, Mary C.;Tanskanen, Antti;Cannon, Mary
目的：作者试图确定产前暴露于感染和阳性精神障碍家族史是否协同作用，以增加日后发展为精神分裂症的风险。作者联系了两个国家登记处，医学出生登记处和芬兰人口登记处，以确定赫尔辛基所有在怀孕期间因上尿路感染接受医院治疗的妇女（N=9，1947年至1990年之间。芬兰医院出院登记被用来确定产前感染的后代成年后的精神状况。精神障碍家族史通过医院出院登记处和人口登记处的联系确定。作者使用了一个添加剂的统计相互作用模型来计算积极的家族史和产前暴露于infection.Results之间的生物协同作用量：产前暴露于感染并没有显着增加精神分裂症的风险。然而，产前暴露于肾盂肾炎的影响是那些有精神病家族史的人的五倍。协同分析表明，估计有38%-46%的后代谁开发的精神分裂症和产前暴露于感染和阳性家族史的精神病disorders.Conclusions的协同作用的结果：这些研究结果支持精神分裂症的病因基因-环境相互作用的机制。
Objective: The authors sought to determine whether prenatal exposure to infection and a positive family history of psychotic disorders interact synergistically to increase the risk of later developing schizophrenia.Method: The authors linked two national registers, the Medical Birth Register and the Finnish Population Register, to identify all women in Helsinki who received hospital treatment during pregnancy for an upper urinary tract infection (N=9,596) between 1947 and 1990. The Finnish Hospital Discharge Register was used to ascertain psychiatric outcomes in adulthood of offspring exposed to infection prenatally. Family history of psychotic disorders was determined by linking the Hospital Discharge Register and the Population Register. The authors used an additive statistical interaction model to calculate the amount of biological synergism between positive family history and prenatal exposure to infection.Results: Prenatal exposure to infection did not significantly increase the risk of schizophrenia. However, the effect of prenatal exposure to pyelonephritis was five times greater in those who had a family history of psychosis compared to those who did not. The synergy analysis suggested that an estimated 38%-46% of the offspring who developed schizophrenia and had both prenatal exposure to infection and a positive family history of psychotic disorders did so as a result of the synergistic action of both risk factors.Conclusions: These findings support a mechanism of gene-environment interaction in the causation of schizophrenia.