Cutaneous Manifestations of Graft‐Versus‐Host Disease
Cutaneous Manifestations of Graft‐Versus‐Host Disease
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移植物抗宿主病的皮肤表现
DOI：
10.1111/j.1365-4362.1981.tb04329.x
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发表时间：
1981
影响因子：
3.6
通讯作者：
J. Saurat
中科院分区：
文献类型：
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作者：
J. Saurat
移植物抗宿主病（GVHD）由一组由GVHD反应（GVHR）引起的临床表现和组织病理学发现组成。这种反应是由于移植组织（移植物）的免疫活性细胞与免疫抑制的组织不相容受体的组织反应。皮肤是GVHD的主要靶器官，识别GVHD引起的皮肤症状是重要的，至少有三个原因：（1）皮肤体征有时是GVHR的首发症状。它们可能是孤立的或主要的临床发现，也可能与其他临床体征相关。皮肤体征的识别可以促进诊断和快速治疗的迅速组织学确认。(2)有时，GVHD的皮肤表现本身非常严重，以至于它们可能导致相当大的发病率和死亡率（例如，中毒性表皮坏死松解症，TEN）或严重的功能性后遗症，如硬化症。(3)GVHR的皮肤表现可能类似于其他皮肤病，如扁平苔藓或TEN。因此，GVHD可以作为一种生物学模型，可以提供一些深入了解其他皮肤病的病理机制。
Graft-versus-host disease (GVHD) consists of a group of clinical manifestations and histopathologic findings that are provoked by what is termed the GVHD reaction (GVHR). This reaction is due to the immune competent cells of a transplanted tissue (the graft) reacting with the tissues of an immunosuppressed, histoincompatible recipient. The skin is a primary target organ for GVHD, and recognition ofthe cutaneous symptoms invoked by GVHD is important for at least three reasons: (1) Tbe cutaneous signs are sometimes the first symptoms of a GVHR. They may be an isolated or a predominant clinical finding or may be associated with other clinical signs. The recognition of cutaneous signs can facilitate a prompt histological confirmation of the diagnosis and rapid treatment. (2) Sometimes the cutaneous manifestations of GVHD themselves are so severe that they can be responsible for considerable morbidity and mortality (eg, toxic epidermal necrolysis, TEN) or gross functional sequela, such as sclerosis. (3) The cutaneous manifestations of GVHR may mimic other dermatoiogic disorders, such as lichen planus or TEN. Therefore, GVHD may serve as a biological model that may provide some insight into the pathomechanisms of other skin diseases.