Regulatory T Cell Modulation of Cytokine and Cellular Networks in Corneal Graft Rejection
Regulatory T Cell Modulation of Cytokine and Cellular Networks in Corneal Graft Rejection
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DOI：
10.1007/s40135-018-0191-2
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发表时间：
2018-10
影响因子：
0.9
通讯作者：
M. Tahvildari;Takenori Inomata;A. Amouzegar;R. Dana
中科院分区：
文献类型：
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作者：
M. Tahvildari;Takenori Inomata;A. Amouzegar;R. Dana
综述目的同种异体角膜移植放置在血管化或炎症的宿主床上，由于宿主床中激活的免疫细胞占优势，移植物排斥反应的风险增加。调节性T细胞(Tregs)是适应性免疫反应的主要调节者，在诱导免疫耐受中起着关键作用。本文就Tregs介导角膜移植耐受的机制以及针对Tregs以提高移植存活率的新的治疗方法进行综述。近年来发现，高危同种异体移植物的炎症环境不仅促进效应T细胞的活化和向移植物部位的渗透，而且还损害Treg的免疫调节功能。最近的研究表明，Tregs的扩张和调节功能的增强显著地提高了移植物的存活率。综述随着我们对角膜移植中细胞和分子通路的了解的加深，新的治疗策略已经被开发出来，以提高同种异体移植物的存活率。在这篇综述中，我们讨论了以Treg为重点的促进同种异体角膜移植物存活的治疗方法。
Purpose of ReviewCorneal allografts placed in vascularized or inflamed host beds are at increased risk of graft rejection due to the preponderance of activated immune cells in the host bed. Regulatory T cells (Tregs) are master regulators of the adaptive immune response and play a key role in the induction of immune tolerance. The aim of this review is to discuss mechanisms through which Tregs mediate tolerance in corneal transplantation and the novel therapeutic approaches that target Tregs to promote transplant survival.Recent FindingsThe inflammatory environment of high-risk allografts not only promotes activation of effector T cells and their infiltration to graft site, but also impairs Treg immunomodulatory function. Recent studies have shown that expansion of Tregs and enhancing their modulatory function significantly improve graft survival.SummaryAs our understanding of the cellular and molecular pathways in corneal transplantation has deepened, novel therapeutic strategies have been developed to improve allograft survival. In this review, we discuss therapeutic approaches that focus on Tregs to promote corneal allograft survival.