SPECIFIC CELLULAR-STIMULATION IN THE PRIMARY IMMUNE-RESPONSE - EXPERIMENTAL TEST OF A QUANTIZED MODEL
SPECIFIC CELLULAR-STIMULATION IN THE PRIMARY IMMUNE-RESPONSE - EXPERIMENTAL TEST OF A QUANTIZED MODEL
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DOI：
10.1073/pnas.79.3.884
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
DINTZIS, HM
中科院分区：
文献类型：
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作者：
DINTZIS, RZ;VOGELSTEIN, B;DINTZIS, HM
剂量-反应和剂量-抑制曲线进行了测量，在小鼠体内和体外的主要免疫反应，使用大小分级线性聚合物的丙烯酰胺取代半抗原。结果是在一般协议与一个简单的理论的基础上的前提下，特定的初级免疫反应是量化的一些基本和限制的步骤，需要最小数量的连接抗原受体的反应。
Dose-response and dose-suppression curves were measured for the primary immune response in mice, in vivo and in vitro, using size-fractionated linear polymers of acrylamide substituted with hapten. The results are in general agreement with a simple theory based on the premise that the specific primary immunological response is quantized at some fundamental and limiting step, requiring a minimum number of linked antigen receptors for response.