Assays of physical stability and antioxidant activity of a topical formulation added with different plant extracts
Assays of physical stability and antioxidant activity of a topical formulation added with different plant extracts
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DOI：
10.1016/j.jpba.2004.10.030
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发表时间：
2005-02-23
影响因子：
3.4
通讯作者：
Fonseca, MJV
中科院分区：
文献类型：
--
作者：
Di Mambro, VM;Fonseca, MJV
在本研究中，在包含含有黄酮类化合物的不同植物提取物后，评价了局部制剂的物理稳定性（pH、粘度、流动指数和触变性）的变化。此外，使用化学发光和稳定的自由基1，1 -二苯基-2-苦基肼（DPPH.）测定，以及脂质过氧化的抑制。使用添加DL-α-生育酚的制剂来比较物理稳定性和抗氧化活性。含有植物提取物的制剂表现出假塑性行为，粘度和触变性降低。光果甘草（GG）和银杏（GB）提取物单独和含有这些提取物的制剂显示出很大的抗氧化和自由基清除活性，而所研究的其他提取物（光果甘草、聚合草和牛蒡根的混合物、美莲和大豆）显示出较低的活性。结果表明，GG和GB提取物可用于局部制剂，以保护皮肤免受自由基和活性氧引起的损伤。(C)2004 Elsevier B. V.保留所有权利。
In the present investigation the changes on physical stability (pH, viscosity, flow index and tixotropy) of topical formulations were evaluated following inclusion of different plant extracts containing flavonoids. Also, the antioxidant effect of these plant extracts alone and after addition, 41 in the formulation was evaluated using chemiluminescence and the stable free radical 1, 1 -diphenyl-2-picrylhydrazyl (DPPH.) assays, as well as the inhibition of lipid peroxidation. Formulation added with DL-alpha-tocopherol was used to compare the physical stability and antioxidant activity. Formulations with plant extracts showed pseudoplastic behavior with decreasing on viscosity and tixotropy. The Glycyrrhiza glabra (GG) and Ginkgo biloba (GB) extracts alone and the formulations containing these extracts showed great antioxidant and free radical scavenging activities while the other extracts studied (mixture of Glycyrrhiza glabra, Symphytum officinale L and Arctium majus root, Nelumbium speciosum and soybean) showed lower activity. The results suggest that GG and GB extracts may be used in topical formulations in order to protect skin against damage caused by free radical and reactive oxygen species. (C) 2004 Elsevier B.V. All rights reserved.