Multi-MHz retinal OCT
Multi-MHz retinal OCT
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DOI：
10.1364/boe.4.001890
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发表时间：
2013-10-01
影响因子：
3.4
通讯作者：
Huber, Robert
中科院分区：
文献类型：
--
作者：
Klein, Thomas;Wieser, Wolfgang;Huber, Robert
我们分析了使用1050 nm傅立叶域锁模(FDML)激光以超过1 MHz的A扫描速率对人体视网膜进行体内光学相干断层扫描(OCT)成像的好处和问题。研究了MHzOCT线速实现的不同扫描策略，提出了一种简单的多体数据处理方法。人体眼底的活体OCT以不同的轴向扫描速率进行，最高可达6.7 MHz。与以前的设置相比，在超宽范围内实现高质量的非散瞳视网膜成像是通过几个关键改进的组合实现的。对于FDML激光器，在419.1 kHz的基频调谐速率下，利用啁啾光纤布拉格光栅在激光器腔内获得了长相干长度和72 nm波长调谐范围。通过从数据采集卡到主计算机存储器的持续数据传输，可以采集非常大的数据集，从而实现许多帧和多个对准数据集的高质量平均。研究了三种成像模式：1.68 MHz轴向线速下24个数据集的对准和平均，3.35 MHz线速下的高密度横向采样，以及6.7 MHz有效线速下视网膜上两个激光光斑的双光束成像。(C)2013年美国光学学会
We analyze the benefits and problems of in vivo optical coherence tomography (OCT) imaging of the human retina at A-scan rates in excess of 1 MHz, using a 1050 nm Fourier-domain mode-locked (FDML) laser. Different scanning strategies enabled by MHz OCT line rates are investigated, and a simple multi-volume data processing approach is presented. In-vivo OCT of the human ocular fundus is performed at different axial scan rates of up to 6.7 MHz. High quality non-mydriatic retinal imaging over an ultra-wide field is achieved by a combination of several key improvements compared to previous setups. For the FDML laser, long coherence lengths and 72 nm wavelength tuning range are achieved using a chirped fiber Bragg grating in a laser cavity at 419.1 kHz fundamental tuning rate. Very large data sets can be acquired with sustained data transfer from the data acquisition card to host computer memory, enabling high-quality averaging of many frames and of multiple aligned data sets. Three imaging modes are investigated: Alignment and averaging of 24 data sets at 1.68 MHz axial line rate, ultra-dense transverse sampling at 3.35 MHz line rate, and dual-beam imaging with two laser spots on the retina at an effective line rate of 6.7 MHz. (c) 2013 Optical Society of America