Prediction of the neurological outcome with intrathecal high mobility group box 1 and S100B in cardiac arrest victims: A pilot study
Prediction of the neurological outcome with intrathecal high mobility group box 1 and S100B in cardiac arrest victims: A pilot study
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DOI：
10.1016/j.resuscitation.2012.01.030
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发表时间：
2012-08-01
期刊：
影响因子：
6.5
通讯作者：
Maekawa, Tsuyoshi
中科院分区：
文献类型：
--
作者：
Oda, Yasutaka;Tsuruta, Ryosuke;Maekawa, Tsuyoshi
Objectives: To investigate whether high mobility group box 1 (HMGB1) and S100B in cerebrospinal fluid (CSF) and the serum predict the neurological outcome in patients resuscitated from out-of-hospital cardiac arrest (OHCA).Materials and methods: This study was designed as a prospective observational study. Twenty-five patients, who received standard cardiopulmonary resuscitation and post-resuscitation intensive care, were enrolled in this study. The patients were divided into two groups according to Glasgow-Pittsburgh Cerebral Performance categories (CPCs) at 6 months after return of spontaneous circulation (ROSC), Group G (n = 7, CPC 1 or 2) and Group P (n = 18, CPC = 3). Their blood samples were taken at 6, 24, and 48 h after ROSC. The patients, whose CSF was sampled at 48 h, were also divided into either sub-Group G (n = 6) or sub-Group P (n = 8) at 6 months after ROSC.Results: HMGB1 and S100B in CSF in sub-Group P were significantly higher than those in sub-Group G (HMGB1,
