The role of palatable food and hunger as trigger factors in an animal model of stress induced binge eating
The role of palatable food and hunger as trigger factors in an animal model of stress induced binge eating
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DOI：
10.1002/eat.10168
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发表时间：
2003-09-01
影响因子：
5.5
通讯作者：
Oswald, KD
中科院分区：
文献类型：
--
作者：
Hagan, MM;Chandler, PC;Oswald, KD
目的：节食和压力是饮食失调的病因因素，节食可以强烈预测非临床人群中压力引起的暴饮暴食。我们开发了一种由压力引起的饱食大鼠暴饮暴食的动物模型，但仅限于有热量限制史的大鼠，并且只有在压力后可获得高度适口的食物（HPF）时。这项研究调查了已知的暴食触发因素（HPF 的味道和饥饿）对此类暴食的影响。方法：雌性大鼠通过 R/S 方案进行循环，但这次仅品尝 HPF 和随意的常规食物。另一个 R/S 循环后，大鼠在限制期间（饥饿时）受到压力，并给予 HPF 和食物。结果：尽管在应激后仅提供食物的情况下不会发生暴饮暴食，但对于仅受限制、仅受应激或两者都没有的大鼠，仅尝一口 HPF 就足以增加食物摄入量，超过 160% (p < 0.001)。饥饿增加了两个限制组消耗食物的比例，但压力通过将 HPF 摄入量增加至仅限制组大鼠的 137%（p < 0.001），从而放大了饥饿引起的暴饮暴食。讨论：这些效应表明，该模型中的暴食是由奖励驱动的，而不是代谢需求，并且与临床暴食症中描述的暴食触发因素的观察结果相似。这增强了使用该动物模型来针对节食和压力之前的饮食失调的生理学和治疗的有效性。 (C) 2003 年，Wiley periodicals, Inc.
Objective: Dieting and stress are etiological factors in eating disorders, and dieting strongly predicts stress-induced overeating in the nonclinical population. We developed an animal model of binge eating in sated rats that is evoked by stress, but only in rats with a history of caloric restriction and only if highly palatable food (HPF) is available after stress. This study investigated the effect of known binge triggers, a taste of HPF and of hunger, on this type of binge eating. Method: Female rats were cycled through the R/S protocol but this time were given just a taste of HPF with ad lib regular chow. After another R/S cycle, rats were stressed during restriction (while hungry) and were given HPF and chow. Results: Although binge eating did not occur if only chow was available after stress, just a taste of HPF sufficed to increase chow intake to more than 160% (p < 0.001) of rats with a history of restriction only, stress-only, or neither. Hunger increased the proportion of chow consumed by both restricted groups, but stress magnified this hunger-induced overeating by increasing HPF intake to 137% of restriction-only rats (p < 0.001). Discussion: These effects suggest that binge eating in this model is motivated by reward, not metabolic need, and parallels observations of binge triggers described in clinical binge-eating disorders. This strengthens the validity of using this animal model to target the physiology and treatment of eating disorders preceded by dieting and stress. (C) 2003 by Wiley Periodicals, Inc.