The effect of acidosis on sympatho-adrenal stimulation. Particular reference to cardiopulmonary bypass.
The effect of acidosis on sympatho-adrenal stimulation. Particular reference to cardiopulmonary bypass.
复制标题
酸中毒对交感肾上腺刺激的影响。
DOI：
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发表时间：
1966
期刊：
影响因子：
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通讯作者：
G. Nahas
中科院分区：
文献类型：
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作者：
J. Malm;W. Manger;S. F. Sullivan;E. M. Papper;G. Nahas
伴随休克的几种因素可引起交感-肾上腺系统的刺激和儿茶酚胺的产生。低血压在引起这种反应中的作用已被彻底研究。刺激肾上腺素和去甲肾上腺素对休克的反应在实验工作和临床情况中都有记载。[1]酸中毒的重要作用尚未得到很好的阐明。本报告总结了该机构最近的工作，与酸中毒在交感肾上腺系统刺激中的作用有关，通过血浆儿茶酚胺水平测定。研究了三种实验模型，以阐明体外循环期间的临床观察结果。Manger等人2先前报道的第一系列实验旨在阐明酸碱控制对不可逆失血性休克后交感肾上腺反应的影响。用Wiggers描述的方法，在杂种狗中产生休克，维持平均动脉血压为50
Stimulation of the the sympatho-adrenal system and catecholamine production are induced by several factors accompanying shock. The role of hypotension in evoking this response has been thoroughly investigated. Stimulation of epinephrine and norepinephrine in response to shock has been previously documented, both in experimental work and in clinical situations. 1 The important role of acidosis has been less well elucidated. This report summarizes recent work in this institution, related to the role of acidosis in the stimulation of a sympathoadrenal system, as measured by plasma catecholamine levels. Three experimental models were studied to elucidate clinical observations made during cardiopulmonary bypass. The first series of experiments previously reported by Manger et al 2 were designed to elucidate the effects of acid-base control on the sympathoadrenal response following irreversible hemorrhagic shock. Shock was produced in mongrel dogs with the preparation described by Wiggers, 3 with maintenance of mean arterial-blood pressure of 50