Nickel-Mediated Asymmetric Allylic Alkylation between Nitroallylic Acetates and Acyl Imidazoles
Nickel-Mediated Asymmetric Allylic Alkylation between Nitroallylic Acetates and Acyl Imidazoles
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镍介导的硝基烯丙基乙酸酯与酰基咪唑之间的不对称烯丙基烷基化
DOI：
10.1021/acs.orglett.7b02264
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发表时间：
2017
期刊：
影响因子：
5.2
通讯作者：
Wang R
中科院分区：
文献类型：
--
作者：
Wang Jie;Wang Pengxin;Wang Linqing;Li Dan;Wang Kezhou;Wang Yuan;Zhu Haiyong;Yang Dongxu;Wang Rui;Yang DX;Wang R
研究了镍催化的咪唑酮与硝基烯丙基乙酸酯的不对称烯丙基烷基化反应。该反应在一种简单的手性二胺-镍催化剂的催化下，在温和的条件下，以中等至良好的产率和优异的对映选择性，得到了一系列新的对映体富集的α-烯丙基加合物。此外，烯丙基加合物的转化可以顺利地以良好的产率得到含有三个连续立构中心的手性γ-硝基酯。
A nickel-mediated asymmetric allylic alkylation reaction between imidazole-modified ketones and nitroallylic acetates is presented. This reaction is catalyzed by a simple chiral diamine-nickel catalyst under mild conditions and leads to a series of novel enantioenriched α-allylic adducts in moderate to good yields with excellent enantioselectivities. Furthermore, transformation of the allylic adducts could smoothly lead to chiral γ-nitro-esters containing three continuous stereocenters in good yields.