Registration-Based Morphometry for Shape Analysis of the Bones of the Human Wrist.
Registration-Based Morphometry for Shape Analysis of the Bones of the Human Wrist.
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DOI：
10.1109/tmi.2015.2476817
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发表时间：
2016-02
影响因子：
10.6
通讯作者：
Chaudhari AJ
中科院分区：
文献类型：
--
作者：
Joshi AA;Leahy RM;Badawi RD;Chaudhari AJ
我们提出了一种方法，量化的人的手腕骨的表面形态的逐点变化。所提出的方法，被称为基于配准的骨形态测量（RBM），包括两个步骤：一个图集选择步骤和图集扭曲步骤。基于到来自健康受试者群体的数据库的腕骨集合的最短l2距离来选择个体腕骨的图谱。然后使用基于正则化l2距离最小化的非线性配准方法将所选图谱扭曲到群体中个体的相应骨骼。由此计算的位移场显示了骨形状的局部差异，然后将其用于组差异分析。我们的研究结果表明，RBM有潜力提供一个标准化的方法来分析人体手腕骨的形状。我们证明了RBM的性能，检查组的差异，手腕骨形状的性别和健康个体的左右手腕之间的。我们还提供了数据，以显示应用RBM跟踪骨侵蚀状态在类风湿性关节炎。
We present a method that quantifies point-wise changes in surface morphology of the bones of the human wrist. The proposed method, referred to as Registration-based Bone Morphometry (RBM), consists of two steps: an atlas selection step and an atlas warping step. The atlas for individual wrist bones was selected based on the shortest l2 distance to the ensemble of wrist bones from a database of a healthy population of subjects. The selected atlas was then warped to the corresponding bones of individuals in the population using a non-linear registration method based on regularized l2 distance minimization. The displacement field thus calculated showed local differences in bone shape that then were used for the analysis of group differences. Our results indicate that RBM has potential to provide a standardized approach to shape analysis of bones of the human wrist. We demonstrate the performance of RBM for examining group differences in wrist bone shapes based on sex and between those of the right and left wrists in healthy individuals. We also present data to show the application of RBM for tracking bone erosion status in rheumatoid arthritis.