A virus in search of a disease

A virus in search of a disease
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DOI:
10.1038/333497a0
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发表时间:
1988-06
期刊:
影响因子:
64.8
通讯作者:
R. Weiss
R. Weiss
中科院分区:
综合性期刊1区
文献类型:
--
作者:
R. Weiss

文献摘要

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逆转录病毒大致分为三个亚科:RNA肿瘤病毒或肿瘤病毒(本身又分为B-、C-和D-型病毒);慢病毒(慢病毒);和泡沫病毒(泡沫病毒)。长期以来,肿瘤病毒一直占据着最大的利益份额。但后来,艾滋病的病原体,人类免疫缺陷病毒(HIV),被归类为慢病毒,这把聚光灯转向缓慢,神经性慢病毒,如维斯纳病毒。泡沫病毒仍然是灰姑娘组,没有与它们相关的重要疾病。现在,位于海德堡的德国癌症研究中心的Rolf Flugel和他的团队已经完成了对人类泡沫病毒(HFV)基因组的分析,HFV具有有趣的特性2
RETROVIRUSES are broadly grouped into three subfamilies: RNA tumour viruses or oncoviruses (themselves subdivided into B-, C-and D-type viruses); slow viruses (lentiviruses); and foamy viruses (spumaviruses)'. Oncoviruses long held the lion's share of the interest. But then, the causative agent of AIDS, human immunodeficiency virus (HIV), was classified as a lentivirus, which turned the spotlight onto slow, neuropathic lentiviruses such as visna virus. Spumaviruses remained the Cinderella group, having no important diseases associated with them. Now, Rolf Flugel and his group at the German Cancer Research Centre in Heidelberg have completed their analysis of the genome of human foamy virus (HFV), which has interesting properties2